NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT), EC 2.4.2.12, is an enzyme that catalyzes the transfer of a phosphoribosyl group from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide, forming nicotinamide mononucleotide (NMN) a key NAD pathway intermediate.

Products
Background
Literature (1)
Gene Data

NAMPT Inhibitors

Cat. No. Product Name / Activity
6753 CHS 828
NAMPT inhibitor; active in vivo and cytotoxic
8072 FK 866
Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
5207 STF 118804
NAMPT inhibitor; depletes leukemia stem cells
4484 STF 31
NAMPT inhibitor; also GLUT1 inhibitor

NAMPT Activators

Cat. No. Product Name / Activity
4076 P7C3
NAMPT activator; also proneurogenic and neuroprotective

Degraders

Cat. No. Product Name / Activity
7842 NAMPT PROTAC® A7
Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)

Nicotinamide phosphoribosyltransferase (NAMPT), EC 2.4.2.12, is an enzyme that catalyzes the transfer of a phosphoribosyl group to nicotinamide (NAM), forming nicotinamide mononucleotide (NMN), which is then converted to nicotinamide adenine dinucleotide (NAD). The formation of NMN is the rate limiting step for the synthesis of NAD, an important intermediate of cell metabolism and redox reactions. Next NAD-dependent enzymes, such as poly (ADP-ribose) polymerase (PARP) and sirtuins, catalyze NAD to produce NAM (the predominant NAD precursor in mammals), which is then recycled by NAMPT, completing the cycle.

NAMPT exists in two forms, intracellular (iNAMPT) and extracellular (eNAMPT). iNAMPT is found in the nucleus, cytoplasm and mitochondria, whereas eNAMPT is found in the extracellular space. The role of iNAMPT is clearly defined as a NAD biosynthetic enzyme. It regulates NAD levels and recycles NAM, which in turn modulates cell metabolism, oxidative stress and inflammation. However the role of eNAMPT (previously known as visfatin and pre-B-cell colony-enhancing factor 1) has not yet been fully defined; current theories include a role as a proinflammatory cytokine, insulin mimetic and NAD biosynthetic enzyme.

Overexpression of NAMPT plays a key role in cancer metabolism because of its modulatory effects on glucose and lipid metabolism, oxidative stress and inflammation. Increased levels of iNAMPT in some cancers, have been linked to angiogenesis through aberrant activation of ERK1/2 pathways, and induction of vascular endothelial growth factor (VEGF) and matrix metalloprotease (MMP) secretion. NAMPT levels are also increased in inflammatory diseases such as Crohn's disease, with eNAMPT possibly acting as a proinflammatory cytokine. Abnormal NAMPT activity has also been linked to diabetes by influencing insulin resistance.

External sources of pharmacological information for NAMPT :

    Literature for NAMPT

    Tocris offers the following scientific literature for NAMPT to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer Metabolism Poster

    Cancer Metabolism Poster

    This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

    NAMPT Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    NAMPT Human NAMPT NM_182790 P43490
    Mouse Nampt NM_021524 Q99KQ4
    Rat Nampt NM_177928 Q80Z29