CHS 828

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Cat.No. 6753 - CHS 828 | C19H22ClN5O | CAS No. 200484-11-3
Description: NAMPT inhibitor; active in vivo and cytotoxic
Chemical Name: N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

NAMPT inhibitor. Decreases cellular level of NAD+. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.

Technical Data

M. Wt 371.86
Formula C19H22ClN5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 200484-11-3
PubChem ID 148198
InChI Key BOIPLTNGIAPDBY-UHFFFAOYSA-N
Smiles ClC1=CC=C(C=C1)OCCCCCCN/C(NC#N)=N/C2=CC=NC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.45 mL 26.89 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Hjarnaa et al (1999) CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 59 5751 PMID: 10582695

Karpov et al (2018) Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates. ACS Med.Chem.Lett. 9 838 PMID: 30128077

Olesen et al (2008) Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem.Biophys.Res.Commun. 367 799 PMID: 18201551


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