You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CHS 828 New
NAMPT inhibitor. Decreases cellular level of NAD+. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.45 mL||26.89 mL|
|5 mM||0.54 mL||2.69 mL||5.38 mL|
|10 mM||0.27 mL||1.34 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the biological activity of the product.
Hjarnaa et al (1999) CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 59 5751 PMID: 10582695
Karpov et al (2018) Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates. ACS Med.Chem.Lett. 9 838 PMID: 30128077
Olesen et al (2008) Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem.Biophys.Res.Commun. 367 799 PMID: 18201551
If you know of a relevant reference for CHS 828, please let us know.
View Related Products by Product Action
Keywords: CHS 828, CHS 828 supplier, CHS828, NAMPT, inhibitors, inhibits, ROS, cytotoxic, active, in, vivo, 6753, Tocris Bioscience
Citations for CHS 828
Citations are publications that use Tocris products.
Currently there are no citations for CHS 828. Do you know of a great paper that uses CHS 828 from Tocris? Please let us know.
Reviews for CHS 828
There are currently no reviews for this product. Be the first to review CHS 828 and earn rewards!
Have you used CHS 828?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.