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Biological Activity for CHS 828
CHS 828 is a NAMPT inhibitor. Decreases cellular level of NAD+. Selectively increases intracellular ROS levels in cancer cells but not normal cells. Active in vivo and cytotoxic.
Compound Libraries for CHS 828
Technical Data for CHS 828
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHS 828
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CHS 828
The following data is based on the product molecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.45 mL||26.89 mL|
|5 mM||0.54 mL||2.69 mL||5.38 mL|
|10 mM||0.27 mL||1.34 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for CHS 828
References are publications that support the biological activity of the product.
Hjarnaa et al (1999) CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo. Cancer Res. 59 5751 PMID: 10582695
Karpov et al (2018) Nicotinamide phosphoribosyltransferase inhibitor as a novel payload for antibody-drug conjugates. ACS Med.Chem.Lett. 9 838 PMID: 30128077
Olesen et al (2008) Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem.Biophys.Res.Commun. 367 799 PMID: 18201551
If you know of a relevant reference for CHS 828, please let us know.
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Citations for CHS 828
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Literature in this Area
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Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.