STF 31

Pricing Availability   Qty
Description: NAMPT inhibitor; also GLUT1 inhibitor
Chemical Name: 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Purity: ≥99% (HPLC)
Citations (8)
Reviews (1)
Literature (2)

Biological Activity for STF 31

STF 31 is an inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.

Compound Libraries for STF 31

STF 31 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for STF 31

M. Wt 423.53
Formula C23H25N3O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 724741-75-7
PubChem ID 984333
Smiles O=C(NC2=CN=CC=C2)C1=CC=C(CNS(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for STF 31

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.35 100

Preparing Stock Solutions for STF 31

The following data is based on the product molecular weight 423.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.81 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets for STF 31

Certificate of Analysis / Product Datasheet
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References for STF 31

References are publications that support the biological activity of the product.

Chan et al (2011) Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 3 94ra70 PMID: 21813754

Adams et al (2014) NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 9 2247 PMID: 25058389

Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 4 483 PMID: 25834119

If you know of a relevant reference for STF 31, please let us know.

View Related Products by Product Action

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Keywords: STF 31, STF 31 supplier, STF31, glut1, glucose, transporters, inhibitors, inhibits, uptake, slc2a1, Glucose, Transporters, NAMPT, ESCs, and, iPSC, 4484, Tocris Bioscience

8 Citations for STF 31

Citations are publications that use Tocris products. Selected citations for STF 31 include:

Xintaropoulou et al (2018) Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment. BMC Cancer 18 636 PMID: 29866066

Nael A et al (2017) Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner. Am J Physiol Lung Cell Mol Physiol 312 L688-L702 PMID: 28213469

Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Mol Cell Biol 4 483 PMID: 25834119

Robert et al (2014) MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer. Mol Cancer 13 239 PMID: 25339305

Do you know of a great paper that uses STF 31 from Tocris? Please let us know.

Reviews for STF 31

Average Rating: 5 (Based on 1 Review.)

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We got a good result.
By Anonymous on 05/07/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: human astrocytes

After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.

PMID: 31439867 Reference
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