Inhibitor of GLUT1; inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Activity causes necrotic cell death in von Hippel-Lindau (VHL)-deficient RCC cells. Also NAMPT inhibitor. Eliminates human pluripotent stem cells from culture with limited toxicity towards differentiated cells.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 423.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.81 mL||23.61 mL|
|5 mM||0.47 mL||2.36 mL||4.72 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References are publications that support the biological activity of the product.
Chan et al (2011) Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci.Transl.Med. 3 94ra70 PMID: 21813754
Adams et al (2014) NAMPT is the cellular target of STF-31-like small-molecule probes. ACS Chem.Biol. 9 2247 PMID: 25058389
Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Stem Cells Transl.Med. 4 483 PMID: 25834119
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Keywords: STF 31, STF 31 supplier, STF31, glut1, glucose, transporters, inhibitors, inhibits, uptake, slc2a1, Glucose, Transporters, NAMPT, ESCs, and, iPSC, 4484, Tocris Bioscience
2 Citations for STF 31
Citations are publications that use Tocris products. Selected citations for STF 31 include:
Xintaropoulou et al (2015) A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget 6 25677 PMID: 26259240
Kropp et al (2015) Inhibition of an NAD+ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. Mol Cell Biol 4 483 PMID: 25834119
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Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.