Monopolar Spindle 1 Kinase

Monopolar spindle 1 (Mps1) kinase, also known as TTK protein kinase, is a mitotic kinase that is critical in the regulation of cell division, as it is involved in controlling the progression of cells through mitosis. It is widely found, but is not ubiquitous, in eukaryotes.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3994 AZ 3146
Potent and selective Mps1 kinase inhibitor
5562 Mps BAY 2a
Potent and selective Mps1 kinase inhibitor
5142 Mps1-IN-1 dihydrochloride
Selective Mps1 kinase inhibitor
4750 TC Mps1 12
Potent and selective Mps1 kinase inhibitor

Monopolar spindle 1 (Mps1) kinase EC 2.7.12.1, also known as TTK protein kinase, is a mitotic kinase that is critical in the regulation of cell division, as it is involved in controlling the progression of cells through mitosis. It is widely found in eukaryotes and the C-terminal kinase domain is highly conserved.

In mammalian cells Mps1 kinase is localized at kinetochores, protein structures on chromatids to which the spindle microtubules attach. The enzyme is essential for the activation and maintenance of the spindle checkpoint, and along with Aurora B kinase acts to ensure that chromosomes are correctly attached to the mitotic spindle before cells can progress from metaphase to anaphase. It is therefore a crucial component of the checkpoint signaling pathway.

Mps1 kinase phosphorylates various components of the spindle pole body and influences, but is not crucial to, the duplication of the centrosome. The enzyme undergoes extensive autophosphorylation, which is essential for activation; it is primarily inactivated by degradation. Expression of Mps1 kinase is dysregulated in a variety of human cancers.

External sources of pharmacological information for Monopolar Spindle 1 Kinase :

    Literature for Monopolar Spindle 1 Kinase

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

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    Cell Cycle & DNA Damage Repair

    Cell Cycle & DNA Damage Repair Poster

    In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

    Monopolar Spindle 1 Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    TTK Human TTK NM_003318 P33981
    Mouse Ttk NP_033471 P35761
    Rat Ttk NM_001108172 NP_001101642