Melanocortin (MC) Receptors

Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3492 ACTH (1-39)
Potent endogenous MC2 agonist
4053 BMS 470539 dihydrochloride
Potent, selective MC1 receptor agonist
2566 Melanotan II
High affinity melanocortin receptor agonist
3424 γ1-MSH
Selective MC3 receptor agonist
4272 [D-Trp8]-γ-MSH
Selective MC3 receptor agonist
3013 [Nle4,D-Phe7]-α-MSH
Melanocortin receptor agonist
2584 α-MSH
Endogenous melanocortin receptor agonist
5094 PG 931
Potent and selective MC4 receptor agonist
3032 THIQ
Potent and selective MC4 receptor agonist

Antagonists

Cat No Product Name / Activity
1831 HS 014
Selective MC4 receptor antagonist
1832 HS 024
Highly potent MC4 receptor antagonist
3426 JKC 363
Potent and selective MC4 receptor antagonist
3438 MCL 0020
Selective MC4 receptor antagonist
4854 ML 00253764 hydrochloride
Melanocortin MC4 receptor antagonist; brain penetrant
5954 MSG 606
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
4919 PG 106
Selective MC3 receptor antagonist

Other

Cat No Product Name / Activity
3611 Lys-γ3-MSH
Pro-opiomelanocortin (POMC) derived peptide
1929 Melanocyte-stimulating hormone release inhibiting factor
Inhibitor of α-MSH release; inhibits opioid effects in vivo
3420 SHU 9119
MC3 and MC4 antagonist; MC5 partial agonist

Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

External sources of pharmacological information for Melanocortin (MC) Receptors :

Literature for Melanocortin (MC) Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Melanocortin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MC1 Human MC1R NM_002386 Q9UN60
Mouse Mc1r NM_008559 Q01727
Rat Mc1r XM_226554 XP_226554
MC2 Human MC2R NM_000529 Q01718
Mouse Mc2r NM_008560 Q64326
Rat Mc2r AF547168 Q8CIX6
MC3 Human MC3R NM_019888 P41968
Mouse Mc3r NM_008561 P33033
Rat Mc3r NM_001025270 P32244
MC4 Human MC4R NM_005912 P32245
Mouse Mc4r NM_016977 P56450
Rat Mc4r NM_013099 P70596
MC5 Human MC5R NM_005913 P33032
Mouse Mc5r NM_013596 P41149
Rat Mc5r NM_013182 P35345