Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.
Melanocortin (MC) Receptor Agonists |
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Cat. No. | Product Name / Activity |
3492 | ACTH (1-39) |
Potent endogenous MC2 agonist | |
2566 | Melanotan II |
High affinity melanocortin receptor agonist | |
3013 | [Nle4,D-Phe7]-α-MSH |
Melanocortin receptor agonist | |
2584 | α-MSH |
Endogenous melanocortin receptor agonist | |
3032 | THIQ |
Potent and selective MC4 receptor agonist | |
Melanocortin (MC) Receptor Antagonists |
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Cat. No. | Product Name / Activity |
1831 | HS 014 |
Selective MC4 receptor antagonist | |
1832 | HS 024 |
Highly potent MC4 receptor antagonist | |
4854 | ML 00253764 hydrochloride |
Melanocortin MC4 receptor antagonist; brain penetrant | |
5954 | MSG 606 |
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist | |
Melanocortin (MC) Receptor Modulators |
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Cat. No. | Product Name / Activity |
6926 | Fenoprofen calcium |
Positive allosteric modulator of MC3 receptors; exhibits biased signaling | |
Other |
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Cat. No. | Product Name / Activity |
3420 | SHU 9119 |
MC3 and MC4 antagonist; MC5 partial agonist |
Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.
Tocris offers the following scientific literature for Melanocortin (MC) Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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MC1 | Human | MC1R | NM_002386 | Q9UN60 |
Mouse | Mc1r | NM_008559 | Q01727 | |
Rat | Mc1r | XM_226554 | XP_226554 | |
MC2 | Human | MC2R | NM_000529 | Q01718 |
Mouse | Mc2r | NM_008560 | Q64326 | |
Rat | Mc2r | AF547168 | Q8CIX6 | |
MC3 | Human | MC3R | NM_019888 | P41968 |
Mouse | Mc3r | NM_008561 | P33033 | |
Rat | Mc3r | NM_001025270 | P32244 | |
MC4 | Human | MC4R | NM_005912 | P32245 |
Mouse | Mc4r | NM_016977 | P56450 | |
Rat | Mc4r | NM_013099 | P70596 | |
MC5 | Human | MC5R | NM_005913 | P33032 |
Mouse | Mc5r | NM_013596 | P41149 | |
Rat | Mc5r | NM_013182 | P35345 |