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Melanocortin (MC) Receptors

Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.

Products
Background
Literature (3)
Gene Data

Melanocortin (MC) Receptor Agonists
Cat. No. Product Name / Activity
3492 ACTH (1-39)
Potent endogenous MC2 agonist
2566 Melanotan II
High affinity melanocortin receptor agonist
3013 [Nle4,D-Phe7]-α-MSH
Melanocortin receptor agonist
2584 α-MSH
Endogenous melanocortin receptor agonist
3032 THIQ
Potent and selective MC4 receptor agonist

Melanocortin (MC) Receptor Antagonists
Cat. No. Product Name / Activity
1831 HS 014
Selective MC4 receptor antagonist
1832 HS 024
Highly potent MC4 receptor antagonist
4854 ML 00253764 hydrochloride
Melanocortin MC4 receptor antagonist; brain penetrant
5954 MSG 606
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Melanocortin (MC) Receptor Modulators
Cat. No. Product Name / Activity
6926 Fenoprofen calcium
Positive allosteric modulator of MC3 receptors; exhibits biased signaling

Other
Cat. No. Product Name / Activity
3420 SHU 9119
MC3 and MC4 antagonist; MC5 partial agonist

Melanocortin receptors are activated by members of the melanocortin family: α-, β- and γ-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). Endogenous antagonists include agouti and agouti-related protein (AgRP). The melanocortin receptors are G-protein-coupled and 5 subtypes exist, MC1-5. The melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

External sources of pharmacological information for Melanocortin (MC) Receptors :

Literature for Melanocortin (MC) Receptors

Tocris offers the following scientific literature for Melanocortin (MC) Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Peptides Involved in Appetite Modulation Scientific Review

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Melanocortin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MC1 Human MC1R NM_002386 Q9UN60
Mouse Mc1r NM_008559 Q01727
Rat Mc1r XM_226554 XP_226554
MC2 Human MC2R NM_000529 Q01718
Mouse Mc2r NM_008560 Q64326
Rat Mc2r AF547168 Q8CIX6
MC3 Human MC3R NM_019888 P41968
Mouse Mc3r NM_008561 P33033
Rat Mc3r NM_001025270 P32244
MC4 Human MC4R NM_005912 P32245
Mouse Mc4r NM_016977 P56450
Rat Mc4r NM_013099 P70596
MC5 Human MC5R NM_005913 P33032
Mouse Mc5r NM_013596 P41149
Rat Mc5r NM_013182 P35345