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Biological Activity for [Nle4,D-Phe7]-α-MSH
[Nle4,D-Phe7]-α-MSH is a synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).
Technical Data for [Nle4,D-Phe7]-α-MSH
(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for [Nle4,D-Phe7]-α-MSH
|Solubility||Soluble to 0.60 mg/ml in water|
Product Datasheets for [Nle4,D-Phe7]-α-MSH
References for [Nle4,D-Phe7]-α-MSH
References are publications that support the biological activity of the product.
Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584
Sawyer et al (1980) 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity. Proc.Natl.Acad.Sci.USA 77 5754
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Keywords: [Nle4,D-phe7]-alpha-MSH, [Nle4,D-phe7]-alpha-MSH supplier, Melanocortin, receptor, agonists, MC, Receptors, [Nle4, D-phe7]-α-MSH, alpha-MSH, MelanotanI, Melanotan, I, MT-I, NDP-a-MSH, 3013, Tocris Bioscience
1 Citation for [Nle4,D-Phe7]-α-MSH
Citations are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:
Schellekens et al (2013) Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181 PMID: 23161547
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.