[Nle4,D-Phe7]-α-MSH

Pricing Availability Delivery Time Qty
Cat.No. 3013 - [Nle4,D-phe7]-alpha-MSH | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 | CAS No. 75921-69-6
Description: Melanocortin receptor agonist
Alternative Names: Melanotan I, MT-I, NDP-α-MSH
Datasheet
Citations (1)
Literature

Biological Activity

Synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).

Technical Data

M. Wt 1646.86
Formula C78H111N21O19
Sequence SYSXEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 75921-69-6
PubChem ID 16132139
InChI Key UAHFGYDRQSXQEB-PWPYQVNISA-N
Smiles CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.60 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1646.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.61 mL 3.04 mL 6.07 mL
5 mM 0.12 mL 0.61 mL 1.21 mL
10 mM 0.06 mL 0.3 mL 0.61 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584

Sawyer et al (1980) 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity. Proc.Natl.Acad.Sci.USA 77 5754 PMID:


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View all Melanocortin (MC) Receptor Agonists

Keywords: [Nle4,D-phe7]-alpha-MSH, supplier, Melanocortin, receptor, agonists, MC, Receptors, [Nle4, D-phe7]-α-MSH, alpha-MSH, MelanotanI, Melanotan, I, MT-I, NDP-a-MSH, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience

1 Citation for [Nle4,D-Phe7]-α-MSH

Citations are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:

Schellekens et al (2013) Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181 PMID: 23161547


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