Synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).
(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.60 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1646.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.61 mL||3.04 mL||6.07 mL|
|5 mM||0.12 mL||0.61 mL||1.21 mL|
|10 mM||0.06 mL||0.3 mL||0.61 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the products' biological activity.
Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584
If you know of a relevant reference for [Nle4,D-Phe7]-α-MSH, please let us know.
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Keywords: [Nle4,D-phe7]-alpha-MSH, supplier, Melanocortin, receptor, agonists, MC, Receptors, [Nle4, D-phe7]-α-MSH, alpha-MSH, MelanotanI, Melanotan, I, MT-I, NDP-a-MSH, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience
1 Citation for [Nle4,D-Phe7]-α-MSH
Citations are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:
Schellekens et al (2013) Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181 PMID: 23161547
Do you know of a great paper that uses [Nle4,D-Phe7]-α-MSH from Tocris? If so please let us know.
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