Pricing Availability   Qty
Description: Melanocortin receptor agonist
Alternative Names: Melanotan I, MT-I, NDP-α-MSH
Purity: ≥95% (HPLC)
Citations (1)
Literature (1)

Biological Activity for [Nle4,D-Phe7]-α-MSH

[Nle4,D-Phe7]-α-MSH is a synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).

Technical Data for [Nle4,D-Phe7]-α-MSH

M. Wt 1646.86
Formula C78H111N21O19

(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 75921-69-6
PubChem ID 16132139
Smiles CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for [Nle4,D-Phe7]-α-MSH

Solubility Soluble to 0.60 mg/ml in water

Product Datasheets for [Nle4,D-Phe7]-α-MSH

Certificate of Analysis / Product Datasheet
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References for [Nle4,D-Phe7]-α-MSH

References are publications that support the biological activity of the product.

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584

Sawyer et al (1980) 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity. Proc.Natl.Acad.Sci.USA 77 5754

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View all Melanocortin (MC) Receptor Agonists

Keywords: [Nle4,D-phe7]-alpha-MSH, [Nle4,D-phe7]-alpha-MSH supplier, Melanocortin, receptor, agonists, MC, Receptors, [Nle4, D-phe7]-α-MSH, alpha-MSH, MelanotanI, Melanotan, I, MT-I, NDP-a-MSH, 3013, Tocris Bioscience

1 Citation for [Nle4,D-Phe7]-α-MSH

Citations are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:

Schellekens et al (2013) Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181 PMID: 23161547

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.