Endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.
(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.60 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1664.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.6 mL||3 mL||6.01 mL|
|5 mM||0.12 mL||0.6 mL||1.2 mL|
|10 mM||0.06 mL||0.3 mL||0.6 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the products' biological activity.
Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584
Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757 PMID: 11792967
Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429 PMID: 16679696
If you know of a relevant reference for α-MSH, please let us know.
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