α-MSH

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Cat.No. 2584 - alpha-MSH | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 | CAS No. 581-05-5
Description: Endogenous melanocortin receptor agonist
Alternative Names: α-Melanotropin, α-Melanocyte-stimulating hormone
Datasheet
Citations
Literature

Biological Activity

Endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data

M. Wt 1664.9
Formula C77H109N21O19S
Sequence SYSMEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 581-05-5
PubChem ID 16132144
InChI Key WHNFPRLDDSXQCL-UAZQEYIDSA-N
Smiles CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.60 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1664.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.6 mL 3 mL 6.01 mL
5 mM 0.12 mL 0.6 mL 1.2 mL
10 mM 0.06 mL 0.3 mL 0.6 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584

Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757 PMID: 11792967

Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429 PMID: 16679696


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Citations for α-MSH

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