HS 014

Pricing Availability   Qty
Description: Selective MC4 receptor antagonist
Purity: ≥95% (HPLC)
Citations (1)
Literature (1)

Biological Activity for HS 014

HS 014 is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.

Technical Data for HS 014

M. Wt 1563.77
Formula C71H94N20O17S2

(Modifications: Cys-1 = N-terminal Ac, X = D-2-Nal, Asp-12 = C-terminal amide, Disulfide bridge: 1-8)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 207678-81-7
PubChem ID 24821295
Smiles CC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HS 014

Solubility Soluble to 1 mg/ml in water

Product Datasheets for HS 014

Certificate of Analysis / Product Datasheet
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References for HS 014

References are publications that support the biological activity of the product.

Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID: 14660013

Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID: 9630346

Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 54 509 PMID: 18082228

If you know of a relevant reference for HS 014, please let us know.

View Related Products by Product Action

View all Melanocortin (MC) Receptor Antagonists

Keywords: HS 014, HS 014 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, HS014, 1831, Tocris Bioscience

1 Citation for HS 014

Citations are publications that use Tocris products. Selected citations for HS 014 include:

Panaro et al (2014) The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. PLoS One 20 1018 PMID: 25453189

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.