You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus.
(Modifications: Cys-1 = N-terminal Ac, X = 2-Nal, Asp-12 = C-terminal amide, Disulfide bridge between 1 - 8)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127 PMID: 14660013
Schioth et al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75 PMID: 9630346
Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 54 509 PMID: 18082228
If you know of a relevant reference for HS 014, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: HS 014, HS 014 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, HS014, 1831, Tocris Bioscience
1 Citation for HS 014
Citations are publications that use Tocris products. Selected citations for HS 014 include:
Panaro et al (2014) The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. PLoS One 20 1018 PMID: 25453189
Do you know of a great paper that uses HS 014 from Tocris? Please let us know.
Reviews for HS 014
There are currently no reviews for this product. Be the first to review HS 014 and earn rewards!
Have you used HS 014?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.