HS 024

Pricing Availability Delivery Time Qty
Cat.No. 1832 - HS 024 | Ac-Cys-Nle-Arg-His-D-Nal-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge: 1 - 9) | CAS No. 212370-59-7
Description: Highly potent MC4 receptor antagonist
Datasheet
Citations (1)
Literature

Biological Activity

Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

Technical Data

M. Wt 1266.5
Formula C58H79N19O10S2
Sequence CXRHXRWGC

(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

Storage Desiccate at -20°C
CAS Number 212370-59-7
PubChem ID 25081552
InChI Key PUOCNCOPVAOMDE-LQXMKOPKSA-N
Smiles CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.50 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1266.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.79 mL 3.95 mL 7.9 mL
5 mM 0.16 mL 0.79 mL 1.58 mL
10 mM 0.08 mL 0.39 mL 0.79 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703 PMID: 11726778

Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517 PMID: 12065241

Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006 PMID: 9832440


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View all Melanocortin (MC) Receptor Antagonists

Keywords: HS 024, supplier, potent, MC4R, receptor, antagonists, Receptors, Melanocortin, HS024, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience

1 Citation for HS 024

Citations are publications that use Tocris products. Selected citations for HS 024 include:

Simamura et al (2015) Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. J Neurochem 10 e0123232 PMID: 25860801


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