ML 00253764 hydrochloride

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Cat.No. 4854 - ML 00253764 hydrochloride | C18H18BrFN2O.HCl | CAS No. 1706524-94-8
Description: Melanocortin MC4 receptor antagonist; brain penetrant
Chemical Name: 2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Non-peptide, melanocortin MC4 receptor antagonist (IC50 values are 320, 810 and 2120 nM for MC4, MC3 and MC5 receptors respectively). Decreases cAMP accumulation in HEK-293 cells expressing the MC4 receptor. Increases food intake and reduces loss of lean body mass in tumor bearing mice. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 413.71
Formula C18H18BrFN2O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1706524-94-8
PubChem ID 90488979
InChI Key KZUMGPQDDCBFBF-UHFFFAOYSA-N
Smiles BrC1=CC(CCC2=C(F)C=CC=C2C3=NCCN3)=C(OC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.14 10
DMSO 41.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 413.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.17 mL
5 mM 0.48 mL 2.42 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Citations for ML 00253764 hydrochloride

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