Lysophosphatidic Acid Receptors
Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include S1P receptors.
|Product Name / Activity
|Selective LPA2 receptor non-lipid agonist
|1-Oleoyl lysophosphatidic acid sodium salt
|Endogenous agonist of LPA1 and LPA2
|Product Name / Activity
|Selective, brain penetrant LPA5 antagonist
|Potent and selective LPA2 receptor antagonist
|LPA1 and LPA3 receptor antagonist
|Potent LPA1 antagonist
|TC LPA5 4
|LPA5 receptor antagonist
Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include sphingosine 1-phosphate (S1P) receptors.
Originally identified as members of the endothelial differentiation gene (edg) family, the gene names for the LPA receptors have recently been updated to LPAR1-LPAR3, with LPAR4-LPAR6 also having been updated to reflect their main physiological ligand, lysophosphatidic acid.
LPA1, LPA2 and LPA3 receptors belong within the EDG family and are widely expressed. Whereas, LPA4 and LPA5 receptors are found within the P2Y gene cluster and expressed in low levels in many tissues but with high expression in the ovary and small intestine respectively. LPA6 has recently been identified and is expressed highly in leukocytes, small intestine and hair cells. Additional receptors have also been identified that may qualify as LPA7-LPA9 receptors based on their activation by LPA, although this is pending the publication of additional evidence concerning identity. LPA receptors regulate a broad range of cellular functions: cell proliferation and survival, migration and chemotaxis, cytoskeletal architecture, cell-cell-contacts and adhesion, Ca2+ homoeostasis and Ca2+-dependent functions. They have been implicated in development, regulation of the cardiovascular, immune and nervous systems, inflammation, atherosclerosis, neuropathic pain, fibrosis in the kidney and lung, as well as male infertility and cancer.
External sources of pharmacological information for Lysophosphatidic Acid Receptors :
Literature for Lysophosphatidic Acid Receptors
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LPA Receptor Gene Data
|Gene Accession No.
|Protein Accession No.