TC LPA5 4

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Cat.No. 4708 - TC LPA5 4 | C23H23ClN2O3 | CAS No. 1393814-38-4
Description: LPA5 receptor antagonist
Chemical Name: 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.

Compound Libraries

TC LPA5 4 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 410.89
Formula C23H23ClN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1393814-38-4
PubChem ID 66552906
InChI Key BNALUYKEGYUHQC-UHFFFAOYSA-N
Smiles ClC(C=C(C3=CC(C(O)=O)=NN3C4=CC=CC(OC)=C4)C=C2)=C2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 2.05 5
DMSO 41.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 410.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.17 mL 24.34 mL
5 mM 0.49 mL 2.43 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kozian et al (2012) Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg.Med.Chem.Lett. 22 5239 PMID: 22801643


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Citations for TC LPA5 4

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Literature in this Area

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Pathways for TC LPA5 4

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