TC LPA5 4

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Cat.No. 4708 - TC LPA5 4 | C23H23ClN2O3 | CAS No. 1393814-38-4
Description: LPA5 receptor antagonist
Chemical Name: 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (7)

Biological Activity

LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.

Compound Libraries

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Technical Data

M. Wt 410.89
Formula C23H23ClN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1393814-38-4
PubChem ID 66552906
InChI Key BNALUYKEGYUHQC-UHFFFAOYSA-N
Smiles ClC(C=C(C3=CC(C(O)=O)=NN3C4=CC=CC(OC)=C4)C=C2)=C2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.09 100

Preparing Stock Solutions

The following data is based on the product molecular weight 410.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.17 mL 24.34 mL
5 mM 0.49 mL 2.43 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Kozian et al (2012) Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg.Med.Chem.Lett. 22 5239 PMID: 22801643


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Keywords: TC LPA5 4, TC LPA5 4 supplier, TCLPA54, LPA, LPA5, Lysophosphatidic, acid, receptors, platelets, aggregation, antagonists, Acid, Receptors, 4708, Tocris Bioscience

2 Citations for TC LPA5 4

Citations are publications that use Tocris products. Selected citations for TC LPA5 4 include:

Kittaka et al (2017) Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1. J Physiol 595 2681 PMID: 28176353

Plastira et al (2017) Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype. J Neuroinflammation 14 253 PMID: 29258556


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Reviews for TC LPA5 4

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TC LPA5 4 in the inhibition of LPA induced proinflammatory phenotype in microglia.
By Joanna Plastira on 10/09/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: BV2 and primary microglia

TC LPA5 4 was used in order to study the role of LPAR5 in murine microglia. The inhibitor was used in many different experimental procedures (WB, IF, qPCR, flow cytometry, functional assays) and the results were consistent..Up to 10µM the inhibitor was well tolerated by the cells. Higher concentrations have not been tested (and were not necessary).

Reference
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