TC LPA5 4
LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 410.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.17 mL||24.34 mL|
|5 mM||0.49 mL||2.43 mL||4.87 mL|
|10 mM||0.24 mL||1.22 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the biological activity of the product.
Kozian et al (2012) Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg.Med.Chem.Lett. 22 5239 PMID: 22801643
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Keywords: TC LPA5 4, TC LPA5 4 supplier, TCLPA54, LPA, LPA5, Lysophosphatidic, acid, receptors, platelets, aggregation, antagonists, Acid, Receptors, 4708, Tocris Bioscience
1 Citation for TC LPA5 4
Citations are publications that use Tocris products. Selected citations for TC LPA5 4 include:
Kittaka et al (2017) Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1. J Physiol 595 2681 PMID: 28176353
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TC LPA5 4 was used in order to study the role of LPAR5 in murine microglia. The inhibitor was used in many different experimental procedures (WB, IF, qPCR, flow cytometry, functional assays) and the results were consistent..Up to 10µM the inhibitor was well tolerated by the cells. Higher concentrations have not been tested (and were not necessary).
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