GRI 977143

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Selective LPA2 receptor non-lipid agonist
Chemical Name: 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for GRI 977143

GRI 977143 is a selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.

Technical Data for GRI 977143

M. Wt 391.44
Formula C22H17NO4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 325850-81-5
PubChem ID 3114900
InChI Key GMVZUCHUOYUMLL-UHFFFAOYSA-N
Smiles O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GRI 977143

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.14 100

Preparing Stock Solutions for GRI 977143

The following data is based on the product molecular weight 391.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for GRI 977143

References are publications that support the biological activity of the product.

Kiss et al (2012) Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol.Pharmacol. 82 1162 PMID: 22968304

Kiss et al (2013) Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochim.Biophys.Acta 1831 117 PMID: 23127512


If you know of a relevant reference for GRI 977143, please let us know.

View Related Products by Product Action

View all Lysophosphatidic Acid Receptor Agonists

Keywords: GRI 977143, GRI 977143 supplier, GRI977143, lysophospholipid, acid, 2, LPA2, inhibitors, inhibits, antiapoptotic, caspases, Bax, PARP-1, cleavage, ERK1/2, ERK, survival, pathway, apoptosis, Other, Apoptosis, Lysophosphatidic, Acid, Receptors, 4779, Tocris Bioscience

Citations for GRI 977143

Citations are publications that use Tocris products.

Currently there are no citations for GRI 977143. Do you know of a great paper that uses GRI 977143 from Tocris? Please let us know.

Reviews for GRI 977143

There are currently no reviews for this product. Be the first to review GRI 977143 and earn rewards!

Have you used GRI 977143?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.