Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.
Lipoxygenase Inhibitors |
|
---|---|
Cat. No. | Product Name / Activity |
1311 | MK 886 |
Inhibitor of 5-lipoxygenase-activating protein (FLAP) | |
6448 | ML 351 |
Selective 12/15 LOX inhibitor; active in vivo | |
2850 | PD 146176 |
Selective 15-lipoxygenase inhibitor | |
0645 | 2-TEDC |
5-, 12-, 15-Lipoxygenase inhibitor | |
3308 | Zileuton |
5-LOX inhibitor; orally bioavailable |
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound.
Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
5-LOX | Human | ALOX5 | NM_000698 | P09917 |
Mouse | Alox5 | NM_009662 | P48999 | |
Rat | Alox5 | NM_012822 | P12527 | |
12R-LOX | Human | ALOX12B | NM_001139 | O75342 |
Mouse | Alox12b | NM_009659 | O70582 | |
Rat | Alox12b | NM_001039377 | Q2KMM4 | |
12S-LOX | Human | ALOX12 | NM_000697 | P18054 |
Mouse | Alox12 | NM_007440 | P39655 | |
Rat | Alox12 | NM_001105798 | XP_213369 | |
15-LOX-1 | Human | ALOX15 | NM_001140 | P16050 |
Mouse | Alox15 | NM_009660 | P39654 | |
Rat | Alox15 | NM_031010 | Q02759 | |
15-LOX-2 | Human | ALOX15B | NM_001039130 | O15296 |
Mouse | Alox8 | NM_009661 | O35936 | |
Rat | Alox15b | NM_153301 | Q8K4F2 | |
E-LOX | Human | ALOXE3 | NM_021628 | Q9BYJ1 |
Mouse | Aloxe3 | NM_011786 | Q9WV07 | |
Rat | Aloxe3 | NM_001105793 | XP_213336 | |
ALOX5AP | Human | ALOX5AP | NM_001204406 | P20292 |
Mouse | Alox5ap | NM_009663 | P30355 | |
Rat | Alox5ap | NM_017260 | P20291 |