Lipoxygenases

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
1761 Baicalein
5- and 12-Lipoxygenase inhibitor
3541 BAY-X 1005
Orally active 5-lipoxygenase activating protein (FLAP) inhibitor
1304 BW-B 70C
5-Lipoxygenase inhibitor
1311 MK 886
Inhibitor of 5-lipoxygenase-activating protein (FLAP)
2850 PD 146176
Selective 15-lipoxygenase inhibitor
2204 STEARDA
Endogenous inhibitor of 5-lipoxygenase
0645 2-TEDC
5-, 12-, 15-Lipoxygenase inhibitor
3308 Zileuton
Orally active 5-LOX inhibitor

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound.

Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

External sources of pharmacological information for Lipoxygenases :

    Literature for Lipoxygenases

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    Lipoxygenase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    5-LOX Human ALOX5 NM_000698 P09917
    Mouse Alox5 NM_009662 P48999
    Rat Alox5 NM_012822 P12527
    12R-LOX Human ALOX12B NM_001139 O75342
    Mouse Alox12b NM_009659 O70582
    Rat Alox12b NM_001039377 Q2KMM4
    12S-LOX Human ALOX12 NM_000697 P18054
    Mouse Alox12 NM_007440 P39655
    Rat Alox12 NM_001105798 XP_213369
    15-LOX-1 Human ALOX15 NM_001140 P16050
    Mouse Alox15 NM_009660 P39654
    Rat Alox15 NM_031010 Q02759
    15-LOX-2 Human ALOX15B NM_001039130 O15296
    Mouse Alox8 NM_009661 O35936
    Rat Alox15b NM_153301 Q8K4F2
    E-LOX Human ALOXE3 NM_021628 Q9BYJ1
    Mouse Aloxe3 NM_011786 Q9WV07
    Rat Aloxe3 NM_001105793 XP_213336
    ALOX5AP Human ALOX5AP NM_001204406 P20292
    Mouse Alox5ap NM_009663 P30355
    Rat Alox5ap NM_017260 P20291