Home / Pharmacology / Enzymes / Oxygenases/Oxidases / Lipoxygenases

Lipoxygenases

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.

Products
Background
Literature (2)
Gene Data

Lipoxygenase Inhibitors
Cat. No. Product Name / Activity
1311 MK 886
Inhibitor of 5-lipoxygenase-activating protein (FLAP)
6448 ML 351
Selective 12/15 LOX inhibitor; active in vivo
2850 PD 146176
Selective 15-lipoxygenase inhibitor
0645 2-TEDC
5-, 12-, 15-Lipoxygenase inhibitor
3308 Zileuton
5-LOX inhibitor; orally bioavailable

Related Targets

    Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound.

    Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

    External sources of pharmacological information for Lipoxygenases :

    Literature for Lipoxygenases

    Tocris offers the following scientific literature for Lipoxygenases to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Cardiovascular Research Product Guide

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure
    Immunology Product Listing

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation

    Lipoxygenase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    5-LOX Human ALOX5 NM_000698 P09917
    Mouse Alox5 NM_009662 P48999
    Rat Alox5 NM_012822 P12527
    12R-LOX Human ALOX12B NM_001139 O75342
    Mouse Alox12b NM_009659 O70582
    Rat Alox12b NM_001039377 Q2KMM4
    12S-LOX Human ALOX12 NM_000697 P18054
    Mouse Alox12 NM_007440 P39655
    Rat Alox12 NM_001105798 XP_213369
    15-LOX-1 Human ALOX15 NM_001140 P16050
    Mouse Alox15 NM_009660 P39654
    Rat Alox15 NM_031010 Q02759
    15-LOX-2 Human ALOX15B NM_001039130 O15296
    Mouse Alox8 NM_009661 O35936
    Rat Alox15b NM_153301 Q8K4F2
    E-LOX Human ALOXE3 NM_021628 Q9BYJ1
    Mouse Aloxe3 NM_011786 Q9WV07
    Rat Aloxe3 NM_001105793 XP_213336
    ALOX5AP Human ALOX5AP NM_001204406 P20292
    Mouse Alox5ap NM_009663 P30355
    Rat Alox5ap NM_017260 P20291