PD 146176

Pricing Availability Delivery Time Qty
Cat.No. 2850 - PD 146176 | C15H11NS | CAS No. 4079-26-9
Description: Selective 15-lipoxygenase inhibitor
Chemical Name: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

Technical Data

M. Wt 237.32
Formula C15H11NS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 4079-26-9
PubChem ID 297589
InChI Key ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C3=C(C(C=CC=C4)=C4SC3)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 100
ethanol 11.87 50

Preparing Stock Solutions

The following data is based on the product molecular weight 237.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.14 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sendobry et al (1997) Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br.J.Pharmacol. 120 1199 PMID: 9105693

Bocan et al (1998) A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136 203 PMID: 9543090

Sordillo et al (2005) Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 76 19 PMID: 15967159


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Keywords: PD 146176, supplier, Selective, 15-lipoxygenase, inhibitors, inhibits, Oxygenases, Oxidases, PD146176, 15-LOX, Lipoxygenase, Tocris Bioscience

1 Citation for PD 146176

Citations are publications that use Tocris products. Selected citations for PD 146176 include:

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Cancer Res 153 2031 PMID: 22633978


Do you know of a great paper that uses PD 146176 from Tocris? If so please let us know.

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Literature in this Area

Cardiovascular

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A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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  • Thrombosis and Hemostasis
  • Atherosclerosis
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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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  • Chemotaxis
  • Complement System
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  • Inflammation

Pathways for PD 146176

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