H+,K+-ATPase

H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

Products
Background
Gene Data

Inhibitors

Cat. No. Product Name / Activity
2582 Lansoprazole
H+,K+-ATPase inhibitor
2583 Omeprazole
H+,K+-ATPase inhibitor
4191 PF 3716556
Selective H+,K+-ATPase inhibitor
1690 SCH 28080
H+,K+-ATPase inhibitor

H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

H+, K+-ATPases are P-type ATPases that exist as heterodimers, consisting of an α- and a β-subunit. The α-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The β-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the α-subunit and is essential for enzyme function.

Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).

External sources of pharmacological information for H+,K+-ATPase :

    H+,K+-ATPase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    α-subunit Human ATP4A NM_000704 P20648
    Mouse Atp4a NM_018731 Q64436
    Rat Atp4a XM_341834 P09626
    β-subunit Human ATP4B NM_000705 P51164
    Mouse Atp4b NM_009724 P50992
    Rat Atp4b NM_012510 P18598