Lovastatin

Pricing Availability   Qty
Description: Potent HMG-CoA reductase inhibitor
Alternative Names: Mevinolin
Chemical Name: (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
Purity: ≥98% (HPLC)
Datasheet
Citations (11)
Reviews (1)
Literature (3)

Biological Activity for Lovastatin

Lovastatin is a potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Indirectly inhibits Rho-GTPase activity by depleting intracellular pool of isoprene residues. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Compound Libraries for Lovastatin

Lovastatin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Lovastatin

M. Wt 404.54
Formula C24H36O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 75330-75-5
PubChem ID 53232
InChI Key PCZOHLXUXFIOCF-BXMDZJJMSA-N
Smiles [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lovastatin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 20.23 50 with gentle warming
DMSO 40.45 100

Preparing Stock Solutions for Lovastatin

The following data is based on the product molecular weight 404.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.72 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

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References for Lovastatin

References are publications that support the biological activity of the product.

Alberts (1988) Discovery, biochemistry and biology of lovas. Am.J.Cardiol. 62 10J PMID: 3055919

Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.U.S.A. 77 3957 PMID: 6933445

Park et al (1999) Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res. 19 3133 PMID: 10652602

Ziegler et al (2017) Rho inhibition by lovas. affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation. Cell Death Dis. 8 e2978 PMID: 28796249


If you know of a relevant reference for Lovastatin, please let us know.

View Related Products by Target

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Keywords: Lovastatin, Lovastatin supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Mevinolin, Reductase, 1530, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Lovastatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

11 Citations for Lovastatin

Citations are publications that use Tocris products. Selected citations for Lovastatin include:

Horlbeck et al (2018) Mapping the Genetic Landscape of Human Cells. Cell 174 953 PMID: 30033366

Saqcena et al (2015) Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Oncotarget 14 2285 PMID: 25945415

Nölting et al (2014) Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice. Endocrinology 155 2377 PMID: 24762141

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942


Do you know of a great paper that uses Lovastatin from Tocris? Please let us know.

Reviews for Lovastatin

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GTPase inhibitor.
By Mengxi Lv on 03/26/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: chondrocyte

used as Rho GTPase activity inhibitor

review image

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