Potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo. Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro. Inactive lactam prodrug of lovastatin hydroxy acid, naturally bioactivated in vivo following oral administration.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||20.23||50mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 404.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.47 mL||12.36 mL||24.72 mL|
|5 mM||0.49 mL||2.47 mL||4.94 mL|
|10 mM||0.25 mL||1.24 mL||2.47 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References are publications that support the products' biological activity.
Alberts (1988) Discovery, biochemistry and biology of lovastatin. Am.J.Cardiol. 62 10J PMID: 3055919
Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.U.S.A. 77 3957 PMID: 6933445
Park et al (1999) Lovastatin-induced inhibition of HL-60 cell proliferation via cell cycle arrest and apoptosis. Anticancer Res. 19 3133 PMID: 10652602
If you know of a relevant reference for Lovastatin, please let us know.
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Keywords: Lovastatin, supplier, HMG-CoA, reductases, inhibitors, inhibits, Mevinolin, HMG-CoA, Reductase, HMG-CoA, Reductase, Tocris Bioscience
4 Citations for Lovastatin
Citations are publications that use Tocris products. Selected citations for Lovastatin include:
Buchovecky et al (2013) A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet 45 1013 PMID: 23892605
Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. J Neurosci 2 1176 PMID: 22202492
Ibrahim et al (2015) The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model. Int J Environ Res Public Health 12 12958 PMID: 26501302
Saqcena et al (2015) Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Oncotarget 14 2285 PMID: 25945415
Do you know of a great paper that uses Lovastatin from Tocris? If so please let us know.
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