Pravastatin sodium salt

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Cat.No. 2318 - Pravastatin sodium salt | C23H35NaO7 | CAS No. 81131-70-6
Description: HMG-CoA reductase inhibitor
Alternative Names: Eptastatin sodium
Chemical Name: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.

Compound Libraries

Pravastatin sodium salt is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 446.51
Formula C23H35NaO7
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 81131-70-6
PubChem ID 16759173
InChI Key VWBQYTRBTXKKOG-IYNICTALSA-M
Smiles [Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.65 100
water 44.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 446.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.4 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hamelin and Turgeon (1998) Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. TiPS 19 26 PMID: 9509899


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Keywords: Pravastatin sodium salt, supplier, HMG-CoA, reductases, inhibitors, inhibits, Eptastatin, sodium, HMG-CoA, Reductase, Tocris Bioscience

1 Citation for Pravastatin sodium salt

Citations are publications that use Tocris products. Selected citations for Pravastatin sodium salt include:

Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Proc Natl Acad Sci U S A 2 1176 PMID: 22202492


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