Rosuvastatin calcium

Pricing Availability   Qty
Description: Potent HMG-CoA reductase inhibitor
Chemical Name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Rosuvastatin calcium

Rosuvastatin calcium is a potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Enhances lentiviral transduction of natural killer cells. Orally bioavailable.

Compound Libraries for Rosuvastatin calcium

Rosuvastatin calcium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rosuvastatin calcium

M. Wt 500.57
Formula C22H27FN3O6S.½Ca
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 147098-20-2
PubChem ID 5282455
Smiles CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rosuvastatin calcium

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.06 100

Preparing Stock Solutions for Rosuvastatin calcium

The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for Rosuvastatin calcium

References for Rosuvastatin calcium

References are publications that support the biological activity of the product.

McTaggart et al (2001) Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 87 28B PMID: 11256847

Gong et al (2020) Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor. Mol.Ther.Methods Clin.Dev. 17 634 PMID: 32300610

If you know of a relevant reference for Rosuvastatin calcium, please let us know.

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1 Citation for Rosuvastatin calcium

Citations are publications that use Tocris products. Selected citations for Rosuvastatin calcium include:

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942

Do you know of a great paper that uses Rosuvastatin calcium from Tocris? Please let us know.

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Literature in this Area

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