Rosuvastatin calcium

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Cat.No. 6343 - Rosuvastatin calcium | C22H27FN3O6S.½Ca | CAS No. 147098-20-2
Description: Potent HMG-CoA reductase inhibitor
Chemical Name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Orally bioavailable.

Technical Data

M. Wt 500.57
Formula C22H27FN3O6S.½Ca
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 147098-20-2
PubChem ID 5282455
InChI Key LALFOYNTGMUKGG-BGRFNVSISA-L
Smiles CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

McTaggart et al (2001) Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 87 28B PMID: 11256847


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Keywords: Rosuvastatin calcium, Rosuvastatin calcium supplier, ZD4522, HMG, CoA, reductase, inhibitors, inhibits, statins, 3-hydroxy-3-methyl-glutaryl-CoA, orally, bioavailable, HMG-CoA, Reductase, 6343, Tocris Bioscience

1 Citation for Rosuvastatin calcium

Citations are publications that use Tocris products. Selected citations for Rosuvastatin calcium include:

Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942


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