Rosuvastatin calcium

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Cat.No. 6343 - Rosuvastatin calcium | C22H27FN3O6S.½Ca | CAS No. 147098-20-2
Description: Potent HMG-CoA reductase inhibitor
Chemical Name: (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent HMG-CoA reductase inhibitor (IC50 = 5.4 nM). Inhibits cholesterol synthesis in rat hepatocytes in vitro and in vivo. Reduces plasma LDL cholesterol levels. Orally bioavailable.

Technical Data

M. Wt 500.57
Formula C22H27FN3O6S.½Ca
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 147098-20-2
PubChem ID 5282455
InChI Key LALFOYNTGMUKGG-BGRFNVSISA-L
Smiles CC(C1=C(C(C2=CC=C(F)C=C2)=NC(N(S(C)(=O)=O)C)=N1)/C=C/[C@@H](O)C[C@@H](O)CC(O[Ca]OC(C[C@H](O)C[C@H](O)/C=C/C(C(C3=CC=C(F)C=C3)=NC(N(S(C)(=O)=O)C)=N4)=C4C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 500.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

McTaggart et al (2001) Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am.J.Cardiol. 87 28B PMID: 11256847


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Keywords: Rosuvastatin calcium, supplier, ZD4522, HMG, CoA, reductase, inhibitors, inhibits, statins, 3-hydroxy-3-methyl-glutaryl-CoA, orally, bioavailable, HMG-CoA, Reductase, HMG-CoA, Reductase, Tocris Bioscience

Citations for Rosuvastatin calcium

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