Home / Pharmacology / Enzymes / Reductases / HMG-CoA Reductase / HMG-CoA Reductase Inhibitors / Pitavastatin calcium

Pitavastatin calcium

Cat. No. 4942 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: HMG-CoA reductase inhibitor
Alternative Names: NK-104
Chemical Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Pitavastatin calcium

Pitavastatin calcium is a synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.

Compound Libraries for Pitavastatin calcium

Pitavastatin calcium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Pitavastatin calcium

M. Wt 440.5
Formula C25H23FNO4.0.5Ca
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 147526-32-7
PubChem ID 5282451
InChI Key RHGYHLPFVJEAOC-FFNUKLMVSA-L
Smiles [Ca++].O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pitavastatin calcium

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.05 100

Preparing Stock Solutions for Pitavastatin calcium

The following data is based on the product molecular weight 440.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

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Product Datasheets for Pitavastatin calcium

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Pitavastatin calcium

References are publications that support the biological activity of the product.

Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770 PMID: 16810078

Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239 PMID: 15854203

Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904 PMID: 9296275

If you know of a relevant reference for Pitavastatin calcium, please let us know.

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1 Citation for Pitavastatin calcium

Citations are publications that use Tocris products. Selected citations for Pitavastatin calcium include:

Laurent et al (2021) Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects. Cancers (Basel) 13 PMID: 34439123

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Literature in this Area

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