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Biological Activity for Pitavastatin calcium
Pitavastatin calcium is a synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.
Compound Libraries for Pitavastatin calcium
Technical Data for Pitavastatin calcium
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pitavastatin calcium
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pitavastatin calcium
The following data is based on the product molecular weight 440.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.27 mL||11.35 mL||22.7 mL|
|5 mM||0.45 mL||2.27 mL||4.54 mL|
|10 mM||0.23 mL||1.14 mL||2.27 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
Product Datasheets for Pitavastatin calcium
References for Pitavastatin calcium
References are publications that support the biological activity of the product.
Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770 PMID: 16810078
Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239 PMID: 15854203
Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904 PMID: 9296275
If you know of a relevant reference for Pitavastatin calcium, please let us know.
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Keywords: Pitavastatin calcium, Pitavastatin calcium supplier, NK-104, HMG, CoA, reductase, inhibitors, inhibits, synthetic, statins, HMG-CoA, Reductase, 4942, Tocris Bioscience
1 Citation for Pitavastatin calcium
Citations are publications that use Tocris products. Selected citations for Pitavastatin calcium include:
Laurent et al (2021) Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects. Cancers (Basel) 13 PMID: 34439123
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