WZB 117

Pricing Availability Delivery Time Qty
Cat.No. 6143 - WZB 117 | C20H13FO6 | CAS No. 1223397-11-2
Description: GLUT inhibitor
Chemical Name: 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

GLUT inhibitor (Ki(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM). Suppresses tumor growth in a nude mouse model.

Technical Data

M. Wt 368.31
Formula C20H13FO6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1223397-11-2
PubChem ID 46830365
InChI Key FRSWCCBXIHFKKY-UHFFFAOYSA-N
Smiles OC1=CC=CC(C(OC2=C(C(F)=CC=C2)OC(C3=CC(O)=CC=C3)=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.83 100
ethanol 36.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 368.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.58 mL 27.15 mL
5 mM 0.54 mL 2.72 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ojelabi et al (2016) WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site. J.Biol.Chem. 291 26762 PMID: 27836974

Liu et al (2012) A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol.Cancer Ther. 11 1672 PMID: 22689530

Koch et al (2015) Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget 6 32748 PMID: 26293674


If you know of a relevant reference for WZB 117, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glucose Transporter Inhibitors

Keywords: WZB 117, supplier, WZB117, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, GLUT3, Glucose, Transporters, Glucose, Transporters, Tocris Bioscience

Citations for WZB 117

Citations are publications that use Tocris products.

Currently there are no citations for WZB 117. Do you know of a great paper that uses WZB 117 from Tocris? If so please let us know.

WZB 117 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used WZB 117?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis