BAY 876

Pricing Availability   Qty
Cat.No. 6199 - BAY 876 | C24H16F4N6O2 | CAS No. 1799753-84-6
Description: Potent and selective GLUT1 inhibitor
Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective GLUT1 inhibitor (IC50 = 2 nM). Displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). Induces cell death in hypoxic conditions in vitro. Inhibits glucose uptake by Hela-MaTu cells. Cell permeable and orally bioavailable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-876 probe summary on the SGC website.

Technical Data

M. Wt 496.42
Formula C24H16F4N6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1799753-84-6
Smiles O=C(NC1=C(C)N(CC2=CC=C(C#N)C=C2)N=C1C(F)(F)F)C3=CC(C(N)=O)=NC4=C3C=CC(F)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 496.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References

References are publications that support the biological activity of the product.

Siebeneicher et al (2016) Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 11 2261 PMID: 27552707


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Cancer

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