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Submit ReviewBAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.
The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.
M. Wt | 496.42 |
Formula | C24H16F4N6O2 |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 1799753-84-6 |
PubChem ID | 118191391 |
InChI Key | BKLJDIJJOOQUFG-UHFFFAOYSA-N |
Smiles | O=C(NC1=C(C)N(CC2=CC=C(C#N)C=C2)N=C1C(F)(F)F)C3=CC(C(N)=O)=NC4=C3C=CC(F)=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 49.64 | 100 |
The following data is based on the product molecular weight 496.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.01 mL | 10.07 mL | 20.14 mL |
5 mM | 0.4 mL | 2.01 mL | 4.03 mL |
10 mM | 0.2 mL | 1.01 mL | 2.01 mL |
50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
References are publications that support the biological activity of the product.
Siebeneicher et al (2016) Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 11 2261 PMID: 27552707
Ma et al (2018) Ovarian cancer relies on glucose transporter 1 to fuel glycolysis and growth: anti-tumor activity of BAY-876. Cancers (Basel) 11 33 PMID: 30602670
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Keywords: BAY 876, BAY 876 supplier, BAY876, potent, selective, GLUT1, inhibitors, inhibits, cell, permeable, orally, bioavailable, Glucose, Transporters, 6199, Tocris Bioscience
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