Potent and selective GLUT1 inhibitor (IC50 = 2 nM). Displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). Induces cell death in hypoxic conditions in vitro. Inhibits glucose uptake by Hela-MaTu cells. Cell permeable and orally bioavailable.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-876 probe summary on the SGC website.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 496.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.01 mL||10.07 mL||20.14 mL|
|5 mM||0.4 mL||2.01 mL||4.03 mL|
|10 mM||0.2 mL||1.01 mL||2.01 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References are publications that support the biological activity of the product.
Siebeneicher et al (2016) Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 11 2261 PMID: 27552707
If you know of a relevant reference for BAY 876, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BAY 876, BAY 876 supplier, BAY876, potent, selective, GLUT1, inhibitors, inhibits, cell, permeable, orally, bioavailable, Glucose, Transporters, 6199, Tocris Bioscience
Citations for BAY 876
Citations are publications that use Tocris products.
Currently there are no citations for BAY 876. Do you know of a great paper that uses BAY 876 from Tocris? Please let us know.
Reviews for BAY 876
There are currently no reviews for this product. Be the first to review BAY 876 and earn rewards!
Have you used BAY 876?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.