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Biological Activity for BAY 876
BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. This compound is cell permeable and orally bioavailable.
External Portal Information for BAY 876
The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.
Technical Data for BAY 876
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAY 876
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BAY 876
The following data is based on the product molecular weight 496.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.01 mL||10.07 mL||20.14 mL|
|5 mM||0.4 mL||2.01 mL||4.03 mL|
|10 mM||0.2 mL||1.01 mL||2.01 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for BAY 876
References are publications that support the biological activity of the product.
Siebeneicher et al (2016) Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 11 2261 PMID: 27552707
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Keywords: BAY 876, BAY 876 supplier, BAY876, potent, selective, GLUT1, inhibitors, inhibits, cell, permeable, orally, bioavailable, Glucose, Transporters, 6199, Tocris Bioscience
Citations for BAY 876
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Literature in this Area
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