BAY 876

Pricing Availability   Qty
Description: Potent and selective GLUT1 inhibitor
Chemical Name: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for BAY 876

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.

External Portal Information for BAY 876

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.

Technical Data for BAY 876

M. Wt 496.42
Formula C24H16F4N6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1799753-84-6
PubChem ID 118191391
Smiles O=C(NC1=C(C)N(CC2=CC=C(C#N)C=C2)N=C1C(F)(F)F)C3=CC(C(N)=O)=NC4=C3C=CC(F)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 876

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.64 100

Preparing Stock Solutions for BAY 876

The following data is based on the product molecular weight 496.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for BAY 876

References are publications that support the biological activity of the product.

Siebeneicher et al (2016) Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 11 2261 PMID: 27552707

Ma et al (2018) Ovarian cancer relies on glucose transporter 1 to fuel glycolysis and growth: anti-tumor activity of BAY-876. Cancers (Basel) 11 33 PMID: 30602670

If you know of a relevant reference for BAY 876, please let us know.

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Citations for BAY 876

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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