γ-Secretase Inhibitors

Cat. No. Product Name / Activity
6363 Avagacestat
Highly potent γ-secretase inhibitor; orally bioavailable
4283 Begacestat
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870 BMS 299897
Potent γ-secretase inhibitor
6476 Compound E
γ-secretase inhibitor; induces neuronal differentiation
2654 Compound W
γ-secretase inhibitor
2634 DAPT
γ-secretase inhibitor
4489 DBZ
γ-secretase inhibitor; inhibits Notch pathway
4495 Flurizan
γ-secretase inhibitor; lowers Aβ42 levels in vitro
2677 JLK 6
Inhibitor of γ-secretase-mediated βAPP processing
2627 L-685,458
Potent and selective γ-secretase inhibitor
6559 LY 450139
γ-secretase pseudo-inhibitor
4000 MRK 560
γ-secretase inhibitor; attenuates amyloid plaque deposition
5751 PF 3084014 hydrobromide
Potent γ-secretase inhibitor

Related Targets