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Elastases

Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue. There are two types of elastases; pancreatic elastase and leukocyte (neutrophil) elastase.

Products
Background
Gene Data

Elastase Inhibitors
Cat. No. Product Name / Activity
5706 BAY 678
Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
5651 ONO 6818
High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
3535 Sivelestat sodium salt
Selective leukocyte elastase inhibitor
2506 SSR 69071
Potent, orally active human leukocyte elastase inhibitor

Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue.

There are two types of elastases; pancreatic elastase (E.C. 3.4.21.36) and leukocyte elastase (also known as neutrophil elastase) (E.C. 3.4.21.37). Pancreatic elastase is a digestive enzyme secreted from the pancreatic acinar cells and exists in a complex with α1-antitrypsin. Leukocyte elastase is a cytoplasmic enzyme that modifies the function of natural killer cells, monocytes and granulocytes. It specifically cleaves Val-X, Ala-X, Leu-X or Met-X peptide bonds.

Elastases have a physiological role in processes such as neutrophil migration, phagocytosis and tissue remodeling, and are known to contribute to the pathology of pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.

External sources of pharmacological information for Elastases :

    Elastase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Elastase 1 Human ELA1 NM_001971 Q9UNI1
    Mouse Ela1 NM_033612 NP_291090
    Rat Ela1 NM_012552 P00773
    Elastase 2 Human ELA2 NM_001972 P08246
    Mouse Ela2 NM_015779 Q3UP87
    Rat Ela2 NM_001106767 XP_234883
    Elastase 2A Mouse Ela2a NM_007919 P05208
    Rat Ela2a NM_012553 P00774
    Elastase 3A Human ELA3A NM_005747 P09093
    Mouse Ela3 NM_026419 NP_080695
    Elastase 3B Human ELA3B NM_007352 P08861
    Rat Ela3b NM_001106692 XP_216566