Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue. There are two types of elastases; pancreatic elastase and leukocyte (neutrophil) elastase.
Elastase Inhibitors |
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Cat. No. | Product Name / Activity |
5706 | BAY 678 |
Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor | |
5651 | ONO 6818 |
High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active | |
3535 | Sivelestat sodium salt |
Selective leukocyte elastase inhibitor | |
2506 | SSR 69071 |
Potent, orally active human leukocyte elastase inhibitor | |
Other |
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Cat. No. | Product Name / Activity |
6389 | BAY 677 |
Inactive control for BAY 678 (Cat.No.5706) |
Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue.
There are two types of elastases; pancreatic elastase (E.C. 3.4.21.36) and leukocyte elastase (also known as neutrophil elastase) (E.C. 3.4.21.37). Pancreatic elastase is a digestive enzyme secreted from the pancreatic acinar cells and exists in a complex with α1-antitrypsin. Leukocyte elastase is a cytoplasmic enzyme that modifies the function of natural killer cells, monocytes and granulocytes. It specifically cleaves Val-X, Ala-X, Leu-X or Met-X peptide bonds.
Elastases have a physiological role in processes such as neutrophil migration, phagocytosis and tissue remodeling, and are known to contribute to the pathology of pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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Elastase 1 | Human | ELA1 | NM_001971 | Q9UNI1 |
Mouse | Ela1 | NM_033612 | NP_291090 | |
Rat | Ela1 | NM_012552 | P00773 | |
Elastase 2 | Human | ELA2 | NM_001972 | P08246 |
Mouse | Ela2 | NM_015779 | Q3UP87 | |
Rat | Ela2 | NM_001106767 | XP_234883 | |
Elastase 2A | Mouse | Ela2a | NM_007919 | P05208 |
Rat | Ela2a | NM_012553 | P00774 | |
Elastase 3A | Human | ELA3A | NM_005747 | P09093 |
Mouse | Ela3 | NM_026419 | NP_080695 | |
Elastase 3B | Human | ELA3B | NM_007352 | P08861 |
Rat | Ela3b | NM_001106692 | XP_216566 |