Elastases

Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue. There are two types of elastases; pancreatic elastase and leukocyte (neutrophil) elastase.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5651 ONO 6818
High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
3535 Sivelestat sodium salt
Selective leukocyte elastase inhibitor
2506 SSR 69071
Potent, orally active human leukocyte elastase inhibitor

Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue.

There are two types of elastases; pancreatic elastase (E.C. 3.4.21.36) and leukocyte elastase (also known as neutrophil elastase) (E.C. 3.4.21.37). Pancreatic elastase is a digestive enzyme secreted from the pancreatic acinar cells and exists in a complex with α1-antitrypsin. Leukocyte elastase is a cytoplasmic enzyme that modifies the function of natural killer cells, monocytes and granulocytes. It specifically cleaves Val-X, Ala-X, Leu-X or Met-X peptide bonds.

Elastases have a physiological role in processes such as neutrophil migration, phagocytosis and tissue remodeling, and are known to contribute to the pathology of pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.

Literature for Elastases

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Elastase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Elastase 1 Human ELA1 NM_001971 Q9UNI1
Mouse Ela1 NM_033612 NP_291090
Rat Ela1 NM_012552 P00773
Elastase 2 Human ELA2 NM_001972 P08246
Mouse Ela2 NM_015779 Q3UP87
Rat Ela2 NM_001106767 XP_234883
Elastase 2A Mouse Ela2a NM_007919 P05208
Rat Ela2a NM_012553 P00774
Elastase 3A Human ELA3A NM_005747 P09093
Mouse Ela3 NM_026419 NP_080695
Elastase 3B Human ELA3B NM_007352 P08861
Rat Ela3b NM_001106692 XP_216566