Sivelestat sodium salt
Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 456.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.19 mL||10.95 mL||21.91 mL|
|5 mM||0.44 mL||2.19 mL||4.38 mL|
|10 mM||0.22 mL||1.1 mL||2.19 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 177 814 PMID: 2049103
Young et al (2007) Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 151 628 PMID: 17471175
Hagiwara et al (2009) Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 58 198 PMID: 19169649
Iwamoto et al (2009) Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 8 606 PMID: 19289399
If you know of a relevant reference for Sivelestat sodium salt, please let us know.
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Keywords: Sivelestat sodium salt, supplier, Selective, leukocyte, elastase, inhibitors, inhibits, Human, Neutrophil, Proteinases, Proteases, ONO5046, ONO-5046, Elastase, Elastase, Tocris Bioscience
1 Citation for Sivelestat sodium salt
Citations are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:
Saadoun et al (2012) Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. J Neurosci 71 323 PMID: 22374891
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Literature in this Area
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