Sivelestat sodium salt

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Cat.No. 3535 - Sivelestat sodium salt | C20H21N2NaO7S | CAS No. 150374-95-1
Description: Selective leukocyte elastase inhibitor
Alternative Names: ONO-5046
Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews

Biological Activity

Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Compound Libraries

Sivelestat sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 456.44
Formula C20H21N2NaO7S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 150374-95-1
PubChem ID 23664980
InChI Key ZAIFANJZUGNYCK-UHFFFAOYSA-M
Smiles [Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 456.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.38 mL 21.91 mL 43.82 mL
2.5 mM 0.88 mL 4.38 mL 8.76 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 177 814 PMID: 2049103

Young et al (2007) Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 151 628 PMID: 17471175

Hagiwara et al (2009) Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 58 198 PMID: 19169649

Iwamoto et al (2009) Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 8 606 PMID: 19289399


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Keywords: Sivelestat sodium salt, Sivelestat sodium salt supplier, Selective, leukocyte, elastase, inhibitors, inhibits, Human, Neutrophil, Proteinases, Proteases, ONO5046, ONO-5046, Elastase, 3535, Tocris Bioscience

4 Citations for Sivelestat sodium salt

Citations are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:

Albrengues et al (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361 PMID: 30262472

Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131

Masood et al (2015) Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats. Am J Physiol Lung Cell Mol Physiol 309 L53 PMID: 26136527

Saadoun et al (2012) Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. J Neurosci 71 323 PMID: 22374891


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