Sivelestat sodium salt

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Cat.No. 3535 - Sivelestat sodium salt | C20H21N2NaO7S | CAS No. 150374-95-1
Description: Selective leukocyte elastase inhibitor
Alternative Names: ONO-5046
Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Compound Libraries

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Technical Data

M. Wt 456.44
Formula C20H21N2NaO7S
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 150374-95-1
PubChem ID 23664980
Smiles [Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 456.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 177 814 PMID: 2049103

Young et al (2007) Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 151 628 PMID: 17471175

Hagiwara et al (2009) Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 58 198 PMID: 19169649

Iwamoto et al (2009) Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 8 606 PMID: 19289399

If you know of a relevant reference for Sivelestat sodium salt, please let us know.

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Keywords: Sivelestat sodium salt, supplier, Selective, leukocyte, elastase, inhibitors, inhibits, Human, Neutrophil, Proteinases, Proteases, ONO5046, ONO-5046, Elastase, Elastase, Tocris Bioscience

1 Citation for Sivelestat sodium salt

Citations are publications that use Tocris products. Selected citations for Sivelestat sodium salt include:

Saadoun et al (2012) Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. J Neurosci 71 323 PMID: 22374891

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