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Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR has a key role in cell growth and proliferation.
|Cat. No.||Product Name / Activity|
|Dihydrofolate reductase inhibitor|
|High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART|
|DHFR inhibitor; also potent inhibitor of multidrug and toxin extrusion (MATE) transporters and STAT3 inhibitor|
Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. Tetrahydrofolate is essential for de novo purine and thymidylate synthesis, hence DHFR has a critical role in cell growth and proliferation.
DHFR is the target for many cancer therapies including methotrexate because it is a key enzyme in cell replication. Basal and regulated DHFR gene expression is controlled by Sp1 and E2F family transcription factors respectively and levels of this enzyme peak at the G1/S cell cycle boundary. Autoregulation, through DHFR-RNA interactions, has also been reported. The human gene encoding this enzyme is localized to 5q11.2-13.2.
Tocris offers the following scientific literature for Dihydrofolate Reductase to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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