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Description: Fluorescent HDAC1/2 probe; suitable for use in TR-FRET and FP assays
Chemical Name: 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-5-(3-(4-(8-(hydroxyamino)-8-oxooctanamido)benzyl)thioureido)benzoic acid
Purity: ≥90% (HPLC)
Biological Activity for SAHA-FITC
SAHA-FITC is a fluorescent HDAC1/2 probe for use as a TR-FRET acceptor for CoraFluor labeling and in fluorescence polarization binding assays. Binds non-selectively to HDAC1 and HDAC2 (Kd values are 56 nM and 132 nM respectively; Ki = 1.5 nM).
Optical Data for SAHA-FITC
| Emission Color | Green |
|---|---|
| λabs | 495 nm |
| λem | 525 nm |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for SAHA-FITC
| M. Wt | 682.75 |
| Formula | C36H34N4O8S |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 1160823-10-8 |
| PubChem ID | 44123666 |
| InChI Key | GQKWRDWQZXNRAB-UHFFFAOYSA-N |
| Smiles | OC(C=C1OC2=C3)=CC=C1C(C4=CC=C(NC(NCC5=CC=C(NC(CCCCCCC(NO)=O)=O)C=C5)=S)C=C4C(O)=O)=C2C=CC3=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SAHA-FITC
References for SAHA-FITC
References are publications that support the biological activity of the product.
Kral et al (2014) Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors. Biochemistry 53 725 PMID: 24450491
Payne and Mazitschek (2022) Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors. Cell Chem.Biol. 29 1140 PMID: 35298895
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Keywords: SAHA-FITC, SAHA-FITC supplier, SAHAFITC, SAHA, FITC, TR-FRET, TRFRET, fluorescence, HDAC, histone, deacetylase, fluorescein, isothiocyanate, and, FP, Assay, Reagents, Class, I, HDACs, 7970, Tocris Bioscience
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