Dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||5.69||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.52 mL||17.59 mL||35.17 mL|
|5 mM||0.7 mL||3.52 mL||7.03 mL|
|10 mM||0.35 mL||1.76 mL||3.52 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the products' biological activity.
Olson et al (2013) Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 56 4816 PMID: 23672185
If you know of a relevant reference for BRD 73954, please let us know.
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Keywords: BRD 73954, supplier, BRD73954, Histone, deacetylase, inhibitors, inhibits, HDAC6, HDAC8, HDAC, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.