BRD 73954

Pricing Availability   Qty
Description: Dual histone deacetylase (HDAC) 6/8 inhibitor
Chemical Name: N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for BRD 73954

BRD 73954 is a dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.

Compound Libraries for BRD 73954

BRD 73954 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BRD 73954

M. Wt 284.31
Formula C16H16N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1440209-96-0
PubChem ID 71680913
Smiles ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRD 73954

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.43 100
ethanol 5.69 20 with gentle warming

Preparing Stock Solutions for BRD 73954

The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for BRD 73954

References are publications that support the biological activity of the product.

Olson et al (2013) Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 56 4816 PMID: 23672185

If you know of a relevant reference for BRD 73954, please let us know.

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Keywords: BRD 73954, BRD 73954 supplier, BRD73954, Histone, deacetylase, inhibitors, inhibits, HDAC6, HDAC8, HDAC, Class, I, HDACs, II, 6284, Tocris Bioscience

Citations for BRD 73954

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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Epigenetics in Cancer Poster

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This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

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