BRD 73954

Pricing Availability Delivery Time Qty
Cat.No. 6284 - BRD 73954 | C16H16N2O3 | CAS No. 1440209-96-0
Description: Dual histone deacetylase (HDAC) 6/8 inhibitor
Chemical Name: N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.

Technical Data

M. Wt 284.31
Formula C16H16N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1440209-96-0
PubChem ID 71680913
InChI Key FIHKWEQJEDRIFS-UHFFFAOYSA-N
Smiles ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.43 100
ethanol 5.69 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.59 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Olson et al (2013) Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 56 4816 PMID: 3672185


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Keywords: BRD 73954, supplier, BRD73954, Histone, deacetylase, inhibitors, inhibits, HDAC6, HDAC8, HDAC, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience

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