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FK 228 is a potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Romidepsin is reviewed on the Chemical Probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.49 mL||92.47 mL||184.95 mL|
|0.5 mM||3.7 mL||18.49 mL||36.99 mL|
|1 mM||1.85 mL||9.25 mL||18.49 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
References are publications that support the biological activity of the product.
Sasakawa et al (2003) Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo. Cancer Lett. 195 161 PMID: 12767524
Matsubara et al (2009) Involvement of extracellular signal-regulated kinase activation in human osteosarcoma cell resistance to the histone deacetylase inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-y J.Pharmacol.Exp.Ther. 328 839 PMID: 19073909
Furumai et al (2002) FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 62 4916 PMID: 12208741
If you know of a relevant reference for FK 228, please let us know.
Keywords: FK 228, FK 228 supplier, FK228, antitumour, antitumor, HDAC, histone, deacetylases, class, I, HDAC1, HDAC2, inhibitors, inhibits, anticancer, FR, 109228, FR109228, Depsipeptide, Romidepsin, 901228, Class, HDACs, 3515, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for FK 228 include:
Pozo et al (2018) Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer. Oncotarget 9 37662 PMID: 30701022
Fukuda et al (2015) Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage. J Pharmacol Exp Ther 106 1050 PMID: 26053117
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