Carboxypeptidases

Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5033 2-MPPA
Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
1380 PMPA (NAALADase inhibitor)
GCP II inhibitor
2675 ZJ 43
Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor

Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups of carboxypeptidases; serine-type carboxypeptidases (E.C. 3.4.16.x), for example carboxypeptidase C, metallocarboxypeptidases (E.C. 3.4.17.x), for example glutamate carboxypeptidase II, and cysteine-type carboxypeptidases (E.C. 3.4.18.x), for example cathepsin X.

These enzymes are involved in a diverse range of biological processes including synthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing and reproduction.

Literature for Carboxypeptidases

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Carboxypeptidase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Metallocarboxypeptidases
GCP II Human FOLH1 NM_004476 Q04609
Mouse Folh1 NM_016770 O35409
Rat Folh1 NM_057185 P70627
Carboxypeptidase M Human CPM NM_001005502 P14384
Mouse Cpm NM_027468 Q80V42
Rat Cpm NM_001108098 XP_235168
Serine-type Carboxypeptidases
Carboxypeptidase C Human CTSA NM_000308 P10619
Mouse Ctsa NM_008906 P16675
Serine Carboxypeptidase 1 Human SCPEP1 NM_021626 Q9HB40
Mouse Scpep1 NM_029023 Q920A5
Rat Scpep1 NM_133383 Q920A6
Cysteine-type Carboxypeptidases
Cathepsin X Human CTSZ NM_001336 Q9UBR2
Mouse Ctsz NM_022325 Q9WUU7
Rat Ctsz NM_183330 Q9R1T3