Carboxypeptidases

Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5033 2-MPPA
Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
1380 PMPA (NAALADase inhibitor)
GCP II inhibitor
2675 ZJ 43
Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor

Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups of carboxypeptidases; serine-type carboxypeptidases (E.C. 3.4.16.x), for example carboxypeptidase C, metallocarboxypeptidases (E.C. 3.4.17.x), for example glutamate carboxypeptidase II, and cysteine-type carboxypeptidases (E.C. 3.4.18.x), for example cathepsin X.

These enzymes are involved in a diverse range of biological processes including synthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing and reproduction.

Literature for Carboxypeptidases

Tocris offers the following scientific literature for Carboxypeptidases to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Carboxypeptidase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Metallocarboxypeptidases
GCP II Human FOLH1 NM_004476 Q04609
Mouse Folh1 NM_016770 O35409
Rat Folh1 NM_057185 P70627
Carboxypeptidase M Human CPM NM_001005502 P14384
Mouse Cpm NM_027468 Q80V42
Rat Cpm NM_001108098 XP_235168
Serine-type Carboxypeptidases
Carboxypeptidase C Human CTSA NM_000308 P10619
Mouse Ctsa NM_008906 P16675
Serine Carboxypeptidase 1 Human SCPEP1 NM_021626 Q9HB40
Mouse Scpep1 NM_029023 Q920A5
Rat Scpep1 NM_133383 Q920A6
Cysteine-type Carboxypeptidases
Cathepsin X Human CTSZ NM_001336 Q9UBR2
Mouse Ctsz NM_022325 Q9WUU7
Rat Ctsz NM_183330 Q9R1T3