Carboxypeptidases
Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.
Inhibitors |
|
|---|---|
| Cat No | Product Name / Activity |
| 5033 | 2-MPPA |
| Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable | |
| 1380 | PMPA (NAALADase inhibitor) |
| GCP II inhibitor | |
| 2675 | ZJ 43 |
| Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor | |
Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups of carboxypeptidases; serine-type carboxypeptidases (E.C. 3.4.16.x), for example carboxypeptidase C, metallocarboxypeptidases (E.C. 3.4.17.x), for example glutamate carboxypeptidase II, and cysteine-type carboxypeptidases (E.C. 3.4.18.x), for example cathepsin X.
These enzymes are involved in a diverse range of biological processes including synthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing and reproduction.
Literature for Carboxypeptidases
Tocris offers the following scientific literature for Carboxypeptidases to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Aptamers
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells
Carboxypeptidase Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Metallocarboxypeptidases | ||||
| GCP II | Human | FOLH1 | NM_004476 | Q04609 |
| Mouse | Folh1 | NM_016770 | O35409 | |
| Rat | Folh1 | NM_057185 | P70627 | |
| Carboxypeptidase M | Human | CPM | NM_001005502 | P14384 |
| Mouse | Cpm | NM_027468 | Q80V42 | |
| Rat | Cpm | NM_001108098 | XP_235168 | |
| Serine-type Carboxypeptidases | ||||
| Carboxypeptidase C | Human | CTSA | NM_000308 | P10619 |
| Mouse | Ctsa | NM_008906 | P16675 | |
| Serine Carboxypeptidase 1 | Human | SCPEP1 | NM_021626 | Q9HB40 |
| Mouse | Scpep1 | NM_029023 | Q920A5 | |
| Rat | Scpep1 | NM_133383 | Q920A6 | |
| Cysteine-type Carboxypeptidases | ||||
| Cathepsin X | Human | CTSZ | NM_001336 | Q9UBR2 |
| Mouse | Ctsz | NM_022325 | Q9WUU7 | |
| Rat | Ctsz | NM_183330 | Q9R1T3 | |
Our New Product guide highlights over 200 new products added in the second half of 2017.
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