Carboxypeptidases

Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5033 2-MPPA
Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
1380 PMPA (NAALADase inhibitor)
GCP II inhibitor
2675 ZJ 43
Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor

Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups of carboxypeptidases; serine-type carboxypeptidases (E.C. 3.4.16.x), for example carboxypeptidase C, metallocarboxypeptidases (E.C. 3.4.17.x), for example glutamate carboxypeptidase II, and cysteine-type carboxypeptidases (E.C. 3.4.18.x), for example cathepsin X.

These enzymes are involved in a diverse range of biological processes including synthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing and reproduction.

External sources of pharmacological information for Carboxypeptidases :

    Literature for Carboxypeptidases

    Tocris offers the following scientific literature for Carboxypeptidases to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Carboxypeptidase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Metallocarboxypeptidases
    GCP II Human FOLH1 NM_004476 Q04609
    Mouse Folh1 NM_016770 O35409
    Rat Folh1 NM_057185 P70627
    Carboxypeptidase M Human CPM NM_001005502 P14384
    Mouse Cpm NM_027468 Q80V42
    Rat Cpm NM_001108098 XP_235168
    Serine-type Carboxypeptidases
    Carboxypeptidase C Human CTSA NM_000308 P10619
    Mouse Ctsa NM_008906 P16675
    Serine Carboxypeptidase 1 Human SCPEP1 NM_021626 Q9HB40
    Mouse Scpep1 NM_029023 Q920A5
    Rat Scpep1 NM_133383 Q920A6
    Cysteine-type Carboxypeptidases
    Cathepsin X Human CTSZ NM_001336 Q9UBR2
    Mouse Ctsz NM_022325 Q9WUU7
    Rat Ctsz NM_183330 Q9R1T3