Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.
Inhibitors |
Cat. No. | Product Name / Activity |
---|---|
5033 | 2-MPPA |
Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable | |
1380 | PMPA (NAALADase inhibitor) |
GCP II inhibitor | |
2675 | ZJ 43 |
Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor |
Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups of carboxypeptidases; serine-type carboxypeptidases (E.C. 3.4.16.x), for example carboxypeptidase C, metallocarboxypeptidases (E.C. 3.4.17.x), for example glutamate carboxypeptidase II, and cysteine-type carboxypeptidases (E.C. 3.4.18.x), for example cathepsin X.
These enzymes are involved in a diverse range of biological processes including synthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing and reproduction.
Tocris offers the following scientific literature for Carboxypeptidases to showcase our products. We invite you to request* your copy today!
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
Metallocarboxypeptidases | ||||
GCP II | Human | FOLH1 | NM_004476 | Q04609 |
Mouse | Folh1 | NM_016770 | O35409 | |
Rat | Folh1 | NM_057185 | P70627 | |
Carboxypeptidase M | Human | CPM | NM_001005502 | P14384 |
Mouse | Cpm | NM_027468 | Q80V42 | |
Rat | Cpm | NM_001108098 | XP_235168 | |
Serine-type Carboxypeptidases | ||||
Carboxypeptidase C | Human | CTSA | NM_000308 | P10619 |
Mouse | Ctsa | NM_008906 | P16675 | |
Serine Carboxypeptidase 1 | Human | SCPEP1 | NM_021626 | Q9HB40 |
Mouse | Scpep1 | NM_029023 | Q920A5 | |
Rat | Scpep1 | NM_133383 | Q920A6 | |
Cysteine-type Carboxypeptidases | ||||
Cathepsin X | Human | CTSZ | NM_001336 | Q9UBR2 |
Mouse | Ctsz | NM_022325 | Q9WUU7 | |
Rat | Ctsz | NM_183330 | Q9R1T3 |