Carboxypeptidases
Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups; serine-type carboxypeptidases, metallocarboxypeptidases, and cysteine-type carboxypeptidases.
Inhibitors |
|
|---|---|
| Cat No | Product Name / Activity |
| 5033 | 2-MPPA |
| Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable | |
| 1380 | PMPA (NAALADase inhibitor) |
| GCP II inhibitor | |
| 2675 | ZJ 43 |
| Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor | |
Carboxypeptidases are a group of enzymes that cleave amino acids from the C'-terminal of proteins and peptides by hydrolysis. There are three subgroups of carboxypeptidases; serine-type carboxypeptidases (E.C. 3.4.16.x), for example carboxypeptidase C, metallocarboxypeptidases (E.C. 3.4.17.x), for example glutamate carboxypeptidase II, and cysteine-type carboxypeptidases (E.C. 3.4.18.x), for example cathepsin X.
These enzymes are involved in a diverse range of biological processes including synthesis of neuroendocrine peptides, blood clotting, growth factor production, wound healing and reproduction.
External sources of pharmacological information for Carboxypeptidases :
Literature for Carboxypeptidases
Tocris offers the following scientific literature for Carboxypeptidases to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Chemogenetics
- Epigenetics
- Fluorescent Imaging
- PROTACs
- Signal Transduction
- Stem Cells
Carboxypeptidase Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Metallocarboxypeptidases | ||||
| GCP II | Human | FOLH1 | NM_004476 | Q04609 |
| Mouse | Folh1 | NM_016770 | O35409 | |
| Rat | Folh1 | NM_057185 | P70627 | |
| Carboxypeptidase M | Human | CPM | NM_001005502 | P14384 |
| Mouse | Cpm | NM_027468 | Q80V42 | |
| Rat | Cpm | NM_001108098 | XP_235168 | |
| Serine-type Carboxypeptidases | ||||
| Carboxypeptidase C | Human | CTSA | NM_000308 | P10619 |
| Mouse | Ctsa | NM_008906 | P16675 | |
| Serine Carboxypeptidase 1 | Human | SCPEP1 | NM_021626 | Q9HB40 |
| Mouse | Scpep1 | NM_029023 | Q920A5 | |
| Rat | Scpep1 | NM_133383 | Q920A6 | |
| Cysteine-type Carboxypeptidases | ||||
| Cathepsin X | Human | CTSZ | NM_001336 | Q9UBR2 |
| Mouse | Ctsz | NM_022325 | Q9WUU7 | |
| Rat | Ctsz | NM_183330 | Q9R1T3 | |
Our New Product guide highlights over 190 new products added in the second half of 2018.
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