PMPA (NAALADase inhibitor)

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Cat.No. 1380 - PMPA (NAALADase inhibitor) | C6H11O7P | CAS No. 173039-10-6
Description: GCP II inhibitor
Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioic acid
Datasheet
Citations
Literature

Biological Activity

Highly potent and selective inhibitor of  glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Technical Data

M. Wt 226.12
Formula C6H11O7P
Storage Desiccate at RT
CAS Number 173039-10-6
PubChem ID 10130754
InChI Key ISEYJGQFXSTPMQ-UHFFFAOYSA-N
Smiles OC(=O)CCC(CP(=O)(O)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 226.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.11 mL 44.22 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jackson et al (1996) Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 39 619 PMID: 8558536

Slusher et al (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 5 1396 PMID: 10581082

Thomas et al (2003) NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 471 177 PMID: 12826236

Rahn et al (2012) Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print] PMID: 23169655


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Citations for PMPA (NAALADase inhibitor)

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