PMPA (NAALADase inhibitor)

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Cat.No. 1380 - PMPA (NAALADase inhibitor) | C6H11O7P | CAS No. 173039-10-6
Description: GCP II inhibitor
Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioic acid

Biological Activity

Highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Technical Data

M. Wt 226.12
Formula C6H11O7P
Storage Desiccate at RT
CAS Number 173039-10-6
PubChem ID 10130754
Smiles OC(=O)CCC(CP(=O)(O)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 22.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 226.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.11 mL 44.22 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Jackson et al (1996) Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 39 619 PMID: 8558536

Slusher et al (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 5 1396 PMID: 10581082

Thomas et al (2003) NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 471 177 PMID: 12826236

Rahn et al (2012) Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print] PMID: 23169655

If you know of a relevant reference for PMPA (NAALADase inhibitor), please let us know.

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