Aquaporins

Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

Products
Background
Literature
Gene Data

Blockers

Cat No Product Name / Activity
5412 TC AQP1 1
Aquaporin 1 (AQP1) channel blocker
5425 TGN 020
Aquaporin 4 (AQP4) channel blocker

Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. AQPs were originally thought to be exclusively permeated by water; however, certain isoforms have been shown to also transport small solutes (glycerol, H2O2), ions (Na+, K+, Cl-) and gases (CO2, ammonia).

There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date. AQP0-2, 4-6 and 8 are generally considered to be exclusively water channels, whereas AQP3, 7, 9 and 10 are referred to as aquaglyceroporins, as they are also permeated by glycerol. The function and substrate specificity of AQP11 and 12 are yet to be determined. AQPs usually adopt a tetramer conformation within the cell membrane, with each monomer consisting of a single aqueous pore that is permeable to water. The movement of water and solutes through AQP channels is a passive process that is dependent on the concentration of the transported molecule.

AQPs are relatively ubiquitously expressed, although each isoform has a specific expression pattern that reflects their function. The AQPs are generally localized to the epithelia of tissues that require a high rate of water flux, where they function to regulate fluid homeostasis, secretion and reabsorption. These tissues include the kidney collecting ducts, lung capillaries, salivary glands and lens of the eye. Due to their role in fluid homeostasis, the AQPs have been associated with multiple disorders including kidney dysfunction, the onset of brain edema and loss of vision. For example AQP4 is highly expressed in mammalian astrocytes and has been implicated in the pathogenesis of cerebral edema, with AQP4 inhibition reducing ischemia-induced brain edema in mice.

Literature for Aquaporins

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
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  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Aquaporins Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AQP0 Human AQP0 NM_012064 P30301
Mouse Aqp0 NM_008600 P51180
Rat Aqp0 NM_001105719 P09011
AQP1 Human AQP1 NM_000385 P29972
Mouse Aqp1 NM_007472 Q02013
Rat Aqp1 NM_012778 P29975
AQP2 Human AQP2 NM_000486 CCDS8792
Mouse Aqp2 NM_009699 P56402
Rat Aqp2 NM_012909 P34080
AQP3 Human AQP3 NM_004925 Q92482
Mouse Aqp3 NM_016689 Q8R2N1
Rat Aqp3 NM_031703 P47862
AQP4 Human AQP4 NM_001650 P55087
Mouse Aqp4 NM_009700.2 P55088
Rat Aqp4 NM_012825 P47863
AQP5 Human AQP5 NM_001651 P55064
Mouse Aqp5 NM_009701 Q9WTY4
Rat Aqp5 NM_012779 P47864
AQP6 Human AQP6 NM_001652 Q13520
Mouse Aqp6 NM_175087 Q8C4A0
Rat Aqp6 NM_022181 Q9WTY0
AQP7 Human AQP7 NM_001170 O14520
Mouse Aqp7 NM_007473 O54794
Rat Aqp7 NM_019157 P56403
AQP8 Human AQP8 NM_001169 O94778
Mouse Aqp8 NM_007474 P56404
Rat Aqp8 NM_019158 P56405
AQP9 Human AQP9 NM_020980 O43315
Mouse Aqp9 NM_022026 Q9JJJ3
Rat Aqp9 NM_022960 P56627
AQP10 Human AQP10 NM_080429 Q96PS8
AQP11 Human AQP11 NM_173039 Q8NBQ7
Mouse Aqp11 NM_175105 Q8BHH1
Rat Aqp11 NM_173105 Q8CHM1
AQP12A Human AQP12A NM_198998 Q8IXF9
Mouse Aqp12 NM_177587 Q8CHJ2
Rat Aqp12a NM_001109009 NP_001102479