TGN 020

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Cat.No. 5425 - TGN 020 | C8H6N4OS | CAS No. 51987-99-6
Description: Aquaporin 4 (AQP4) channel blocker
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Technical Data

M. Wt 206.22
Formula C8H6N4OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51987-99-6
PubChem ID 4173511
InChI Key AGEGZHOPKZFKBP-UHFFFAOYSA-N
Smiles O=C(NC1=NN=CS1)C2=CN=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.12 20
1eq. HCl 2.06 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 24.25 mL 121.23 mL 242.46 mL
1 mM 4.85 mL 24.25 mL 48.49 mL
2 mM 2.42 mL 12.12 mL 24.25 mL
10 mM 0.48 mL 2.42 mL 4.85 mL

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References

References are publications that support the biological activity of the product.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629


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Keywords: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience

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Ion Channel

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