TGN 020

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Cat.No. 5425 - TGN 020 | C8H6N4OS | CAS No. 51987-99-6
Description: Aquaporin 4 (AQP4) channel blocker
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Compound Libraries

TGN 020 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 206.22
Formula C8H6N4OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51987-99-6
PubChem ID 4173511
InChI Key AGEGZHOPKZFKBP-UHFFFAOYSA-N
Smiles O=C(NC1=NN=CS1)C2=CN=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.12 20
2eq.HCl 2.06 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 24.25 mL 121.23 mL 242.46 mL
1 mM 4.85 mL 24.25 mL 48.49 mL
2 mM 2.42 mL 12.12 mL 24.25 mL
10 mM 0.48 mL 2.42 mL 4.85 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629


If you know of a relevant reference for TGN 020, please let us know.

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Keywords: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience

1 Citation for TGN 020

Citations are publications that use Tocris products. Selected citations for TGN 020 include:

Wang et al (2017) Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1. J Biol Chem 292 8291 PMID: 28360106


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Literature in this Area

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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

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