TGN 020

Pricing Availability Delivery Time Qty
Cat.No. 5425 - TGN 020 | C8H6N4OS | CAS No. 51987-99-6
Description: Aquaporin 4 (AQP4) channel blocker
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Technical Data

M. Wt 206.22
Formula C8H6N4OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51987-99-6
PubChem ID 4173511
InChI Key AGEGZHOPKZFKBP-UHFFFAOYSA-N
Smiles O=C(NC1=NN=CS1)C2=CN=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 2.06 10mM with gentle warming
DMSO 4.12 20

Preparing Stock Solutions

The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.85 mL 24.25 mL 48.49 mL
5 mM 0.97 mL 4.85 mL 9.7 mL
10 mM 0.48 mL 2.42 mL 4.85 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629


If you know of a relevant reference for TGN 020, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Aquaporin Blockers

Keywords: TGN020 aquaporin AQP4 channels blockers ischemia Aquaporins

Citations for TGN 020

Citations are publications that use Tocris products.

Currently there are no citations for TGN 020. Do you know of a great paper that uses TGN 020 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for TGN 020

Protocols

TODO: Add Protocols