You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for TGN 020
TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
Compound Libraries for TGN 020
Technical Data for TGN 020
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TGN 020
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|2eq.HCl||2.06||10 with gentle warming|
Preparing Stock Solutions for TGN 020
The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||24.25 mL||121.23 mL||242.46 mL|
|1 mM||4.85 mL||24.25 mL||48.49 mL|
|2 mM||2.42 mL||12.12 mL||24.25 mL|
|10 mM||0.48 mL||2.42 mL||4.85 mL|
References for TGN 020
References are publications that support the biological activity of the product.
Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301
Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267
Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629
If you know of a relevant reference for TGN 020, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience
2 Citations for TGN 020
Citations are publications that use Tocris products. Selected citations for TGN 020 include:
Harrison et al (2020) Impaired glymphatic function and clearance of tau in an Alzheimer's disease model. Brain 143 2576 PMID: 32705145
Wang et al (2017) Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1. J Biol Chem 292 8291 PMID: 28360106
Do you know of a great paper that uses TGN 020 from Tocris? Please let us know.
Reviews for TGN 020
There are currently no reviews for this product. Be the first to review TGN 020 and earn rewards!
Have you used TGN 020?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.