Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. HCl||2.06||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||24.25 mL||121.23 mL||242.46 mL|
|1 mM||4.85 mL||24.25 mL||48.49 mL|
|2 mM||2.42 mL||12.12 mL||24.25 mL|
|10 mM||0.48 mL||2.42 mL||4.85 mL|
References are publications that support the biological activity of the product.
Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301
Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267
Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629
If you know of a relevant reference for TGN 020, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience
Citations for TGN 020
Citations are publications that use Tocris products.
Currently there are no citations for TGN 020. Do you know of a great paper that uses TGN 020 from Tocris? Please let us know.
Reviews for TGN 020
There are currently no reviews for this product. Be the first to review TGN 020 and earn rewards!
Have you used TGN 020?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.