Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. HCl||2.06||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.85 mL||24.25 mL||48.49 mL|
|5 mM||0.97 mL||4.85 mL||9.7 mL|
|10 mM||0.48 mL||2.42 mL||4.85 mL|
|50 mM||0.1 mL||0.48 mL||0.97 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301
Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267
Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629
If you know of a relevant reference for TGN 020, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: TGN020 aquaporin AQP4 channels blockers ischemia Aquaporins
Citations for TGN 020
Citations are publications that use Tocris products.
Currently there are no citations for TGN 020. Do you know of a great paper that uses TGN 020 from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells