TGN 020

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Cat.No. 5425 - TGN 020 | C8H6N4OS | CAS No. 51987-99-6
Description: Aquaporin 4 (AQP4) channel blocker
Chemical Name: N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Purity: ≥99% (HPLC)
Citations (2)
Literature (1)

Biological Activity for TGN 020

TGN 020 is an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice.

Compound Libraries for TGN 020

TGN 020 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TGN 020

M. Wt 206.22
Formula C8H6N4OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51987-99-6
PubChem ID 4173511
Smiles O=C(NC1=NN=CS1)C2=CN=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TGN 020

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.12 20
2eq.HCl 2.06 10 with gentle warming

Preparing Stock Solutions for TGN 020

The following data is based on the product molecular weight 206.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 24.25 mL 121.23 mL 242.46 mL
1 mM 4.85 mL 24.25 mL 48.49 mL
2 mM 2.42 mL 12.12 mL 24.25 mL
10 mM 0.48 mL 2.42 mL 4.85 mL

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Product Datasheets for TGN 020

Certificate of Analysis / Product Datasheet
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References for TGN 020

References are publications that support the biological activity of the product.

Huber et al (2009) Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg.Med.Chem. 17 411 PMID: 18182301

Igarashi et al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324 PMID: 23462267

Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113 PMID: 20924629

If you know of a relevant reference for TGN 020, please let us know.

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Keywords: TGN 020, TGN 020 supplier, TGN020, aquaporin, AQP4, channels, blockers, ischemia, Aquaporins, 5425, Tocris Bioscience

2 Citations for TGN 020

Citations are publications that use Tocris products. Selected citations for TGN 020 include:

Harrison et al (2020) Impaired glymphatic function and clearance of tau in an Alzheimer's disease model. Brain 143 2576 PMID: 32705145

Wang et al (2017) Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1. J Biol Chem 292 8291 PMID: 28360106

Do you know of a great paper that uses TGN 020 from Tocris? Please let us know.

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Literature in this Area

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Ion Channel Product Listing

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
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