TC AQP1 1

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Cat.No. 5412 - TC AQP1 1 | C12H10O4 | CAS No. 37710-81-9
Description: Aquaporin 1 (AQP1) channel blocker
Chemical Name: 3,3'-(1,3-Phenylene)bis(2-propenoic acid)
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Aquaporin 1 (AQP1) channel blocker (IC50 = 8 μM). Inhibits water flux in Xenopus oocytes.

Technical Data

M. Wt 218.211
Formula C12H10O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 37710-81-9
PubChem ID 794091
InChI Key KRXUBZPHAPGHPE-YDFGWWAZSA-N
Smiles O=C(O)/C=C/C1=CC(/C=C/C(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 218.211. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.83 mL
5 mM 0.92 mL 4.58 mL 9.17 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Seeliger et al (2013) Discovery of novel human aquaporin-1 blockers. ACS Chem.Biol. 8 249 PMID: 23113556


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Keywords: TC AQP1 1, supplier, TCAQP11, aquaporin1, channels, blockers, AQP1, Aquaporins, Aquaporins, Tocris Bioscience

Citations for TC AQP1 1

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Literature in this Area

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