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Cat.No. 5412 - TC AQP1 1 | C12H10O4 | CAS No. 37710-81-9
Description: Aquaporin 1 (AQP1) channel blocker
Chemical Name: 3,3'-(1,3-Phenylene)bis(2-propenoic acid)
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Aquaporin 1 (AQP1) channel blocker (IC50 = 8 μM). Inhibits water flux in Xenopus oocytes.

Technical Data

M. Wt 218.211
Formula C12H10O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 37710-81-9
PubChem ID 794091
Smiles O=C(O)/C=C/C1=CC(/C=C/C(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 218.211. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.83 mL
5 mM 0.92 mL 4.58 mL 9.17 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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References are publications that support the biological activity of the product.

Seeliger et al (2013) Discovery of novel human aquaporin-1 blockers. ACS Chem.Biol. 8 249 PMID: 23113556

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Literature in this Area

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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels