Adenosine Kinase

Adenosine kinase (ADK) is a highly conserved monomeric enzyme that constitutes the primary route of adenosine metabolism under normal conditions. ADK decreases intracellular adenosine levels by catalyzing its conversion into AMP and ADP, using ATP as a phosphate donor.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
2372 ABT 702 dihydrochloride
Adenosine kinase inhibitor; orally active
1745 5-Iodotubercidin
Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Adenosine kinase (ADK) is a highly conserved monomeric enzyme that constitutes the primary route of adenosine metabolism under normal conditions. ADK acts to decrease intracellular adenosine levels by catalyzing its conversion into AMP and ADP, using ATP as a phosphate donor and a divalent cation, for example Mg2+, as a co-factor.

ADK is regulated by inorganic phosphate levels, the concentration of local free Mg2+ and contains a NXXE motif that is vital for phosphate activation. Inhibition of this enzyme has been implicated in tissue-protective mechanisms against various physiological stresses, including ischemia, seizures, pain and inflammation, thus there is much interest in developing pharmacological ADK inhibitors.

External sources of pharmacological information for Adenosine Kinase :

    Literature for Adenosine Kinase

    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Adeonsine Kinase Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human ADK NM_001123 P55263
    Mouse Adk NM_134079 P55264
    Rat Adk NM_012895 Q64640