Adenosine Kinase

Adenosine kinase (ADK) is a highly conserved monomeric enzyme that constitutes the primary route of adenosine metabolism under normal conditions. ADK decreases intracellular adenosine levels by catalyzing its conversion into AMP and ADP, using ATP as a phosphate donor.

Products
Background
Literature (1)
Gene Data

Adeonsine Kinase Inhibitors

Cat. No. Product Name / Activity
2372 ABT 702 hydrochloride
Adenosine kinase inhibitor; orally active
1745 5-Iodotubercidin
Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Adenosine kinase (ADK) is a highly conserved monomeric enzyme that constitutes the primary route of adenosine metabolism under normal conditions. ADK acts to decrease intracellular adenosine levels by catalyzing its conversion into AMP and ADP, using ATP as a phosphate donor and a divalent cation, for example Mg2+, as a co-factor.

ADK is regulated by inorganic phosphate levels, the concentration of local free Mg2+ and contains a NXXE motif that is vital for phosphate activation. Inhibition of this enzyme has been implicated in tissue-protective mechanisms against various physiological stresses, including ischemia, seizures, pain and inflammation, thus there is much interest in developing pharmacological ADK inhibitors.

External sources of pharmacological information for Adenosine Kinase :

Literature for Adenosine Kinase

Tocris offers the following scientific literature for Adenosine Kinase to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Adeonsine Kinase Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADK NM_001123 P55263
Mouse Adk NM_134079 P55264
Rat Adk NM_012895 Q64640