ABT 702 hydrochloride

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Description: Adenosine kinase inhibitor; orally active
Chemical Name: 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for ABT 702 hydrochloride

ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Technical Data for ABT 702 hydrochloride

M. Wt 499.79
Formula C22H19N6OBr.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2624336-92-9
PubChem ID 16760265
Smiles NC1=C2C(N=C(C3=CN=C(N4CCOCC4)C=C3)C=C2C5=CC(Br)=CC=C5)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ABT 702 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.66 100

Preparing Stock Solutions for ABT 702 hydrochloride

The following data is based on the product molecular weight 499.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10 mL 20.01 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for ABT 702 hydrochloride

Certificate of Analysis / Product Datasheet
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3 Citations for ABT 702 hydrochloride

Citations are publications that use Tocris products. Selected citations for ABT 702 hydrochloride include:

Hobson et al (2012) Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats. Neuropharmacology 63 1172 PMID: 22749927

Fassett et al (2011) Adenosine kinase regulation of cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol 300 H1722 PMID: 21335462

Ahwazi et al (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochem J 478 2977 PMID: 34259310

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