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Description: Potent and selective A3 adenosine receptor antagonist
Chemical Name: N-[4-(3,5-Dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity for DPTN

DPTN is a potent and selective A3 adenosine receptor antagonist (Ki values are in the range 0.36 - 1.65 nM (hA3AR) and 1.6 - 8.53 nM (rA3AR)). Reduces intrapulmonary pressure when combined with Dexamethasone (Cat. No. 1126). Readily crosses the blood brain barrier in rats.

Technical Data for DPTN

M. Wt 459.39
Formula C22H18N4OS.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 325767-87-1
Smiles CC1=CC(C2=C(C3=CC=NC=C3)SC(NC(C4=CN=CC=C4)=O)=N2)=CC(C)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DPTN

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.19 20 with gentle warming

Preparing Stock Solutions for DPTN

The following data is based on the product molecular weight 459.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.88 mL 54.42 mL 108.84 mL
1 mM 2.18 mL 10.88 mL 21.77 mL
2 mM 1.09 mL 5.44 mL 10.88 mL
10 mM 0.22 mL 1.09 mL 2.18 mL

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References for DPTN

References are publications that support the biological activity of the product.

Gao et al (2021) Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists. Purinergic Signal. 17 737 PMID: 34713378

Suresh et al (2022) Selective A3 adenosine receptor antagonist radioligand for human and rodent species. ACS Med.Chem.Lett. 13 623 PMID: 35450351

If you know of a relevant reference for DPTN, please let us know.

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Citations for DPTN

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