IB-MECA

Pricing Availability   Qty
Description: A3 selective agonist
Alternative Names: CF 101,Piclidenoson
Chemical Name: 1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide
Purity: ≥97% (HPLC)
Datasheet
Citations (12)
Reviews

Biological Activity for IB-MECA

IB-MECA is a potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.

Licensing Information

Sold with the permission of the NIH, US Patent 08/091,109

Technical Data for IB-MECA

M. Wt 510.29
Formula C18H19IN6O4
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 152918-18-8
PubChem ID 123683
InChI Key HUJXGQILHAUCCV-MOROJQBDSA-N
Smiles IC1=CC=CC(CNC2=NC=NC3=C2N=CN3[C@@H]4O[C@H]([C@@](NC)=O)[C@@H](O)[C@H]4O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IB-MECA

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25

Preparing Stock Solutions for IB-MECA

The following data is based on the product molecular weight 510.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 7.84 mL 39.19 mL 78.39 mL
1.25 mM 1.57 mL 7.84 mL 15.68 mL
2.5 mM 0.78 mL 3.92 mL 7.84 mL
12.5 mM 0.16 mL 0.78 mL 1.57 mL

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Product Datasheets for IB-MECA

Certificate of Analysis / Product Datasheet
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References for IB-MECA

References are publications that support the biological activity of the product.

Gallo-Rodriguez et al (1994) Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists. J.Med.Chem. 37 636 PMID: 8126704

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832

Park et al (2006) N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3β. J.Pharmacol.Exp.Ther. 318 124 PMID: 16611852


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Keywords: IB-MECA, IB-MECA supplier, A3, selective, agonists, Receptors, adenosines, CF, 101, Piclidenoson, Adenosine, 1066, Tocris Bioscience

12 Citations for IB-MECA

Citations are publications that use Tocris products. Selected citations for IB-MECA include:

Eusemann et al (2015) Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One 10 e0134934 PMID: 26263491

Janes et al (2014) A3 adenosine receptor agonist prevents the development of PacT.-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain 155 2560 PMID: 25242567

He et al (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J 27 3446 PMID: 23682121

Kozma et al (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol 85 1171 PMID: 23376019


Do you know of a great paper that uses IB-MECA from Tocris? Please let us know.

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