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Description: High affinity selective A3 agonist
Chemical Name: 2-(1-Hexynyl)-N-methyladenosine
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for HEMADO

HEMADO is a high affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).

Compound Libraries for HEMADO

HEMADO is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HEMADO

M. Wt 361.4
Formula C17H23N5O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 403842-38-6
PubChem ID 10981286
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(NC)=NC(C#CCCCC)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for HEMADO

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 36.14 100
DMSO 36.14 100

Preparing Stock Solutions for HEMADO

The following data is based on the product molecular weight 361.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for HEMADO

References are publications that support the biological activity of the product.

Klotz et al (2006) [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 556 14 PMID: 17126322

Volpini et al (2002) N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 45 3271 PMID: 12109910

If you know of a relevant reference for HEMADO, please let us know.

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Keywords: HEMADO, HEMADO supplier, High, affinity, selective, A3, agonists, Receptors, adenosines, Adenosine, 1579, Tocris Bioscience

2 Citations for HEMADO

Citations are publications that use Tocris products. Selected citations for HEMADO include:

Stoddart et al (2012) Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol 19 1105 PMID: 22999879

Gomez et al (2011) Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. Mol Cell Proteomics 31 479 PMID: 21437670

Do you know of a great paper that uses HEMADO from Tocris? Please let us know.

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