HEMADO

Pricing Availability Delivery Time Qty
Cat.No. 1579 - HEMADO | C17H23N5O4 | CAS No. 403842-38-6
Description: High affinity selective A3 agonist
Chemical Name: 2-(1-Hexynyl)-N-methyladenosine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

High affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).

Compound Libraries

HEMADO is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 361.4
Formula C17H23N5O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 403842-38-6
PubChem ID 10981286
InChI Key KOCIMZNSNPOGOP-IWCJZZDYSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(NC)=NC(C#CCCCC)=N2)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.14 100
ethanol 36.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Klotz et al (2006) [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 556 14 PMID: 17126322

Volpini et al (2002) N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 45 3271 PMID: 12109910


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Keywords: HEMADO, supplier, High, affinity, selective, A3, agonists, Receptors, adenosines, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience

2 Citations for HEMADO

Citations are publications that use Tocris products. Selected citations for HEMADO include:

Stoddart et al (2012) Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol 19 1105 PMID: 22999879

Gomez et al (2011) Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. Mol Cell Proteomics 31 479 PMID: 21437670


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