Glutamate (Ionotropic) Receptors
NMDA, AMPA and Kainate receptors are members of the ionotropic class of glutamate receptors. This heterogeneous group of ion channels exist as cation-selective tetramers formed by homo- and hetero-oligomeric assembly of subunits. Common structural features include an extracellular N'-terminal, three transmembrane domains, a channel lining re-entrant 'p-loop' and an intracellular C'-terminal.
Glutamate (Ionotropic) Receptor Target Files
Ionotropic glutamate receptors represent the major excitatory neurotransmitter pathway in the brain and consequently, they are essential for normal CNS function. However, they are also implicated in numerous pathologies including Alzheimer's disease, stroke, schizophrenia, Parkinson's disease, motor neuron disease and depression.