Sodium Channels

Sodium channels are integral membrane proteins that form a Na+ permeable pore through the plasma membrane and allow ion flux. There are two very different types of sodium channels: voltage-gated sodium channels (NaV) and epithelial sodium channels (ENaC). NaV are present in the membrane of most excitable cells and exist as heterodimers or heterotrimers of 1 α- and 1 or 2 β-subunits. ENaC are present in absorptive epithelia, such as the distal kidney tubule, alveolar epithelium and distal colon, and are responsible for sodium reabsorption. They exist as heterotetramers of α-, β- and γ-subunits, the predominant one being 2α:1β:1γ.

Sodium Channel Target Files

Related Categories
Location Subtype TTX Sensitive? Conductance (pS)
Brain I, II, IIA, III, VI Yes 2.5-25
Skeletal muscle μ1 Yes 2.5-25
Sympathetic ganglia PN1 Yes 6.3-10.7
Heart h1 No (IC50 6 μM) 2.5-25
Dorsal root ganglia PN3/SNS No (IC50 ~ 60 μM) 3.4-6.3

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