Sodium channels are integral membrane proteins that form a Na+ permeable pore through the plasma membrane and allow ion flux. There are two very different types of sodium channels: voltage-gated sodium channels (NaV) and epithelial sodium channels (ENaC). NaV are present in the membrane of most excitable cells and exist as heterodimers or heterotrimers of 1 α- and 1 or 2 β-subunits. ENaC are present in absorptive epithelia, such as the distal kidney tubule, alveolar epithelium and distal colon, and are responsible for sodium reabsorption. They exist as heterotetramers of α-, β- and γ-subunits, the predominant one being 2α:1β:1γ.
Sodium Channel Target Files
|Location||Subtype||TTX Sensitive?||Conductance (pS)|
|Brain||I, II, IIA, III, VI||Yes||2.5-25|
|Heart||h1||No (IC50 6 μM)||2.5-25|
|Dorsal root ganglia||PN3/SNS||No (IC50 ~ 60 μM)||3.4-6.3|
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