Acid-Sensing Ion Channels

Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system.

Products
Background
Literature (3)
Gene Data

Activators

Cat. No. Product Name / Activity
0442 4-Chlorophenylguanidine hydrochloride
ASIC3 positive allosteric modulator
5028 GMQ hydrochloride
Selective ASIC3 opener
3647 Neuropeptide SF (mouse, rat)
ASIC3 activator; neuropeptide FF receptor agonist

Blockers

Cat. No. Product Name / Activity
0890 Amiloride hydrochloride
Non-specific ASIC blocker; Na+ channel blocker
4804 APETx2
ASIC3 channel blocker
6705 Diminazene aceturate
ASIC blocker; antihyperalgesic
5042 Psalmotoxin 1
Potent and selective ASIC1a channel blocker

Other

Cat. No. Product Name / Activity
5938 Mambalgin 1
Selective ASIC1a inhibitor; analgesic

Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system. They are voltage-insensitive, Na+ permeable channels that are activated by low extracellular pH.

ASIC subunits contain two putative transmembrane domains and assemble as homotrimers or heterotrimers. To date, five genes of the ASIC family have been identified. ASICs 1-3 are expressed in nociceptive sensory neurons and are involved in regulating mechanoceptor and nociceptor function. They are upregulated in the dorsal root ganglion (DRG) and spinal cord in response to inflammation, and have a role in visceral and cutaneous mechanosensation. ASICs 1 and 2 are additionally expressed in the central nervous system and, because they are sensitive to acid, are implicated in conditions associated with ischemia and local acidosis, such as stroke and multiple sclerosis. ASIC1a, 1b and 2a, 2b are splice variants of ASIC1 and ASIC2, respectively. ASIC4 is expressed in many brain regions, as well as in the spinal cord and cerebellum, and may be involved in modulating fear and anxiety, while ASIC5 is an orphan member of the family, which is abundantly expressed in the cerebellum and to a lesser extent in the brain, liver and intestine.

External sources of pharmacological information for Acid-Sensing Ion Channels :

    Literature for Acid-Sensing Ion Channels

    Tocris offers the following scientific literature for Acid-Sensing Ion Channels to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

    Acid-Sensing Ion Channel Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Acid-Sensing Ion Channel 1 Human ASIC1 NM_020039 P78348
    Mouse Asic1 NM_009597 Q6NXK8
    Rat Asic1 NM_024154 NP_077068
    Acid-Sensing Ion Channel 2 Human ASIC2 NM_183377 Q16515
    Mouse Asic2 NM_007384 Q925H0
    Rat Asic2 NM_012892 NP_037024
    Acid-Sensing Ion Channel 3 Human ASIC3 NM_004769 Q9UHC3
    Mouse Asic3 NM_183000 Q6X1Y6
    Rat Asic3 NM_173135 NP_775158
    Acid-Sensing Ion Channel 4 Human ASIC4 NM_018674 Q96FT7
    Mouse Asic4 NM_183022 Q7TNS7
    Rat Asic4 NP_898843 NP_071570
    Acid-Sensing Ion Channel 5 Human ASIC5 NM_017419 Q9NY37
    Mouse Asic5 NP_067345 Q9R0Y1
    Rat Asic5 NM_022227 NP_071563