Acid-Sensing Ion Channels

Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system.

Literature (3)
Gene Data


Cat. No. Product Name / Activity
0442 4-Chlorophenylguanidine hydrochloride
ASIC3 positive allosteric modulator
5028 GMQ hydrochloride
Selective ASIC3 opener
3647 Neuropeptide SF (mouse, rat)
ASIC3 activator; neuropeptide FF receptor agonist


Cat. No. Product Name / Activity
0890 Amiloride hydrochloride
Non-specific ASIC blocker; Na+ channel blocker
4804 APETx2
ASIC3 channel blocker
6705 Diminazene aceturate
ASIC blocker; antihyperalgesic
5927 NS 383
ASIC blocker; active in vivo
5042 Psalmotoxin 1
Potent and selective ASIC1a channel blocker


Cat. No. Product Name / Activity
5938 Mambalgin 1
Selective ASIC1a inhibitor; analgesic

Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system. They are voltage-insensitive, Na+ permeable channels that are activated by low extracellular pH.

ASIC subunits contain two putative transmembrane domains and assemble as homotrimers or heterotrimers. To date, five genes of the ASIC family have been identified. ASICs 1-3 are expressed in nociceptive sensory neurons and are involved in regulating mechanoceptor and nociceptor function. They are upregulated in the dorsal root ganglion (DRG) and spinal cord in response to inflammation, and have a role in visceral and cutaneous mechanosensation. ASICs 1 and 2 are additionally expressed in the central nervous system and, because they are sensitive to acid, are implicated in conditions associated with ischemia and local acidosis, such as stroke and multiple sclerosis. ASIC1a, 1b and 2a, 2b are splice variants of ASIC1 and ASIC2, respectively. ASIC4 is expressed in many brain regions, as well as in the spinal cord and cerebellum, and may be involved in modulating fear and anxiety, while ASIC5 is an orphan member of the family, which is abundantly expressed in the cerebellum and to a lesser extent in the brain, liver and intestine.

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    Literature for Acid-Sensing Ion Channels

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    Acid-Sensing Ion Channel Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Acid-Sensing Ion Channel 1 Human ASIC1 NM_020039 P78348
    Mouse Asic1 NM_009597 Q6NXK8
    Rat Asic1 NM_024154 NP_077068
    Acid-Sensing Ion Channel 2 Human ASIC2 NM_183377 Q16515
    Mouse Asic2 NM_007384 Q925H0
    Rat Asic2 NM_012892 NP_037024
    Acid-Sensing Ion Channel 3 Human ASIC3 NM_004769 Q9UHC3
    Mouse Asic3 NM_183000 Q6X1Y6
    Rat Asic3 NM_173135 NP_775158
    Acid-Sensing Ion Channel 4 Human ASIC4 NM_018674 Q96FT7
    Mouse Asic4 NM_183022 Q7TNS7
    Rat Asic4 NP_898843 NP_071570
    Acid-Sensing Ion Channel 5 Human ASIC5 NM_017419 Q9NY37
    Mouse Asic5 NP_067345 Q9R0Y1
    Rat Asic5 NM_022227 NP_071563