Cat. No. 5982
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hy
Biological ActivityMetabolite of ketamine (Cat.No. 3131). Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo. 2S,2S- and 2R,6R-enantiomers available. 2R,6R-enantiomer lacks ketamine-related side effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481. PMID: 27144355.
Leung and Baillie (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396. PMID: 3783598.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses cis-6-Hydroxynorketamine hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: cis-6-Hydroxynorketamine hydrochloride, supplier, ketamine, metabolite, antidepressant, AMPA, Tocris Bioscience, Ketamine and Metabolite products
Find multiple products by catalog number
New Products in this Area
Photocrosslinker for hydrogelsGA3-AM
Gibberellin-analog (GA3) chemical dimerizer; cell permeableBicine
General purpose bufferACES
Buffer widely used in Western blottingCORM 2
Carbon monoxide-releasing molecule(S)-Norketamine hydrochloride
NMDA receptor modulator; analgesic2S,6S-Hydroxynorketamine hydrochloride
Decreases D-serine (a NMDA co-agonist); antidepressant2R,6R-Hydroxynorketamine hydrochloride
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects(R)-Norketamine hydrochloride
NMDA receptor modulator; analgesicHaXS8
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.