Cat. No. 5982
Chemical Name: cis-2-Amino-2-(2-chlorophenyl)-6-hy
Biological ActivityMetabolite of ketamine (Cat.No. 3131). Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo. 2S,2S- and 2R,6R-enantiomers available. 2R,6R-enantiomer lacks ketamine-related side effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481. PMID: 27144355.
Leung and Baillie (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396. PMID: 3783598.
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Keywords: cis-6-Hydroxynorketamine hydrochloride, supplier, ketamine, metabolite, antidepressant, AMPA, Tocris Bioscience, Ketamine and Metabolite products
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