Salubrinal

Cat. No. 2347

Salubrinal C21H17N4OSCl3 [405060-95-9]

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Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Technical Data

M.Wt:
479.81
Formula:
C21H17N4OSCl3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
405060-95-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935. PMID: 15705855.

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849. PMID: 16002288.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Salubrinal include:

Tran et al (2014) Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9 2796. PMID: 25279668.

Wan et al (2014) Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow. PLoS One 9 e105699. PMID: 25157407.

Hahn and Lowrey (2013) Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood 122 477. PMID: 23690448.

Konrad et al (2013) Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrob Agents Chemother 57 1815. PMID: 23380722.

Bennett et al (2011) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis 1 e72. PMID: 21364676.

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Keywords: Salubrinal, supplier, Selective, inhibitors, inhibits, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products

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