Cat. No. 2252
Alternative Names: Adriamycin, NSC 123127
Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo
Biological ActivityAntitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Dickey et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 1 6. PMID: 16930453.
Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727. PMID: 10075079.
Patel et al (1997) Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cyotoxicity. Mol.Pharmacol. 52 658. PMID: 9380029.
Skladanowski and Konopa (1993) Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem.Pharmacol. 46 357. PMID: 8347161.
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Citations are publications that use Tocris products. Selected citations for Doxorubicin hydrochloride include:
Smyth et al (2015) Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release 199 145. PMID: 25523519.
Sundaresan et al (2014) Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications. Int J Pharm 466 1. PMID: 24607216.
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641. PMID: 24265703.
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Keywords: Doxorubicin hydrochloride, supplier, Antitumor, antibiotics, agent, inhibitors, inhibits, DNA, topoisomerase, II, Isomerases, NSC123127, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products