New Products

View all new products by date added

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat No Product Name / Activity Date Added
6429 ML 210 Mar 2019
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis
6490 GNE 2861 Mar 2019
Group II PAK inhibitor; potently inhibits PAK4 and PAK 6
6827 Artesunate Mar 2019
Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial
6706 DPNB-ABT 594 Mar 2019
Caged ABT 594; suitable for one- or two-photon photolysis
6830 Conivaptan hydrochloride Mar 2019
Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable
6819 Mefloquine hydrochloride Mar 2019
Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal
6272 KYP 2047 Mar 2019
High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant
6605 dTAG 13 Mar 2019
Degrades mutant FKBPF36V fusion proteins; useful alternative to genetic methods for target validation
6760 Raphin 1 Mar 2019
Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant
6754 LJI308 Mar 2019
Potent pan-RSK inhibitor
6850 Thalidomide - linker 6 Mar 2019
Thalidomide-AlkylC2-Amine
6834 Auxin Mar 2019
Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone
1304 BW-B 70C Mar 2019
5-Lipoxygenase inhibitor
6439 JNJ 0966 Mar 2019
Pro-MMP9 activation inhibitor
6812 Afatinib dimaleate Mar 2019
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
6692 WM 1119 Mar 2019
High affinity KAT6A (MOZ) competitive inhibitor
6664 Kinesore Mar 2019
Kinesin-1 modulator; cell permeable
6851 Pomalidomide - linker 7 Mar 2019
Pomalidomide-alkylC2-amine
6755 Darapladib Mar 2019
Potent lp-PLA2 inhibitor
6518 BI 01383298 Feb 2019
Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor
6724 CBA Feb 2019
Selective TRPM4 blocker
6802 6 TMR Tre Feb 2019
Fluorescent trehalose; selectively labels mycobacterial cell envelope
6809 L-DON Feb 2019
Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
6702 Cerulenin Feb 2019
Irreversible fatty acid synthase inhibitor
6816 Sitagliptin phosphate Feb 2019
Potent and selective DPP IV inhibitor
6798 Click N-Acetylmuramic acid - alkyne Feb 2019
Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes
6266 Taxol Janelia Fluor® 646 Feb 2019
Red fluorescent taxol derivative
6653 FM19G11 Feb 2019
HIF α-subunit inhibitor
6759 AA 147 Feb 2019
ER proteostasis regulator
6786 BzF Feb 2019
Photoreactive unnatural amino acid
3719 Talabostat mesylate Feb 2019
Potent DPP IV inhibitor; activates NLRP1b inflammasome
6597 SPRi 3 Feb 2019
Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells
6793 Dasatinib Feb 2019
Highly potent pan-Src/Bcr-Abl inhibitor
6659 sBADA Feb 2019
Green fluorescent D-amino acid for labeling peptidoglycans in bacteria
6719 YH 239-EE Feb 2019
Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
6470 A 410099.1 Feb 2019
High affinity XIAP antagonist; active in vivo
6695 CHIR 98014 Feb 2019
Highly potent and selective GSK-3 inhibitor; improves insulin sensitivity
6535 NVP 2 Feb 2019
Potent and selective ATP-competitive CDK9 inhibitor
6577 Pyridone 6 Feb 2019
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
6566 STAD 2 Feb 2019
AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
6567 RI-STAD 2 Feb 2019
AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
6705 Diminazene aceturate Feb 2019
ASIC blocker; antihyperalgesic
6245 SM 16 Jan 2019
Potent TGF-βRI inhibitor; orally bioavailable
6715 A 71915 Jan 2019
Highly potent and competitive NPRA antagonist
6621 TFAX 488, TFP Jan 2019
Green fluorescent dye; amine reactive
6668 ML 184 Jan 2019
Selective GPR55 agonist; also promotes NSC proliferation and differentiation
6644 KuWal151 Jan 2019
Potent and selective CLK inhibitor
6553 JF-NP-26 Jan 2019
Caged Raseglurant (Cat. No. 4416)
6607 dTRIM 24 Jan 2019
TRIM24 degrading PROTAC
6726 T-peptide Jan 2019
Cytotoxic Tau peptide; cell permeable
6777 TAK 375 Jan 2019
Very high affinity and selective melatonin receptor agonist
6334 THDOC Jan 2019
Positive modulator of GABAA receptors; endogenous neurosteroid
5984 LY 2955303 Jan 2019
High affinity and selective RARγ antagonist
6698 ELA-11 (human) Jan 2019
High affinity apelin agonist
6709 GSK 2018682 Jan 2019
S1P1 and S1P5 agonist
6788 Quizartinib Jan 2019
Highly potent FLT3 inhibitor
6697 ELA-21 (human) Jan 2019
High affinity apelin agonist
6774 16673-34-0 NLRP3i Jan 2019
NLRP3 inflammasome inhibitor
6243 ML 385 Jan 2019
Nrf2 inhibitor; phenotypically lethal
6598 OD 36 hydrochloride Jan 2019
Potent RIP2 kinase inhibitor
6606 dBRD9 Jan 2019
Potent and selective BRD9 degrading PROTAC
6369 GNE 9278 Jan 2019
Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
6352 (S)-ZINC 3573 Jan 2019
Negative control for (R)-ZINC 3573
6684 VH 032 - linker 6 Jan 2019
VH 032-PEG2-alkyne
6681 Pomalidomide - linker 2 Jan 2019
Pomalidomide-PEG3-carboxylic acid
6680 VH 032 - linker 5 Jan 2019
VH 032-alkylC4-terminal carboxylic acid
6699 [D-Ala2]-GIP (human) Jan 2019
Highly potent GIP agonist
6685 Thalidomide, propargyl Jan 2019
Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
6682 Pomalidomide - linker 3 Jan 2019
Pomalidomide-alkylC5-carboxylic acid
6683 VH 032, propargyl Jan 2019
Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs
6340 Epiblastin A Jan 2019
CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal
6351 (R)-ZINC 3573 Jan 2019
MRGPRX2 agonist
6689 GI 530159 Jan 2019
TREK1 and TREK2 channel activator
6686 Thalidomide - linker 5 Jan 2019
Thalidomide-PEG2-alkyne
6541 AZD 2098 Jan 2019
Potent and selective CCR4 antagonist
6582 D-3 Dec 2018
Selective PSC eliminating agent
6742 Acetazolamide Dec 2018
Carbonic anhydrase inhibitor
6488 5(6)-SFX (Fluorescein), SE Dec 2018
Green fluorescent dye for the labeling of primary amines
6712 A 77-01 Dec 2018
Potent inhibitor of TGF-βRI
6618 MB 05032 Dec 2018
Potent FBPase inhibitor; promotes HSC expansion
6590 Janelia Fluor® 646, Maleimide Dec 2018
Red fluorescent dye, supplied with a maleimide reactive group
6579 BAY 826 Dec 2018
Potent Tie2 inhibitor
6587 TAK 242 Dec 2018
TLR4 signaling inhibitor
6530 R 121919 hydrochloride Dec 2018
High affinity CRF1 antagonist; orally bioavailable
5497 ent-LP 99 Dec 2018
Negative Control for LP 99
5496 LP 99 Dec 2018
Selective BRD7 and BRD9 inhibitor
5782 Phalloidin-FITC Dec 2018
Green fluorescent cytoskeleton stain
6177 AZ 13705339 Dec 2018
Highly potent PAK1 and PAK2 inhibitor
6625 TFAX 594, SE Dec 2018
Red fluorescent dye; amine reactive
6652 NGI 1 Dec 2018
Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
6279 JNJ 39758979 dihydrochloride Dec 2018
High affinity and selective histamine H4 receptor antagonist; orally bioavailable
5783 Phalloidin-TRITC Dec 2018
Red-orange fluorescent cytoskeleton stain
6622 Phalloidin-TFAX 488 Dec 2018
Green fluorescent cytoskeletal stain; binds F-actin
TB4423-GMP CHIR 99021 Dec 2018
CHIR 99021 synthesized to cGMP guidelines
6710 Darunavir Dec 2018
Highly potent HIV protease inhibitor
6676 IC 261 Dec 2018
CK1 inhibitor; displays selectivity for CK1δ and CK1ε
6654 VAS 2870 Dec 2018
NADPH oxidase (Nox) inhibitor
6624 TFAX 568, SE Dec 2018
Orange fluorescent dye; amine reactive
6704 Indo 1AM Nov 2018
Fluorescent Ca2+ indicator
6203 GSK 9311 hydrochloride Nov 2018
Negative control for GSK 6853
6503 Janelia Fluor® 549, free acid Nov 2018
Yellow fluorescent dye; supplied as a free acid
6640 ReZolve-ER™ Nov 2018
Fluorescent ER and plasma membrane stain
6580 PKUMDL WQ 2101 Nov 2018
Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
6325 TM N1324 Nov 2018
Potent and selective GPR39 agonist; orally bioavailable
6626 AP C5 Nov 2018
Potent and selective PKG2 inhibitor
6651 (2R/S)-6-PNG Nov 2018
CaV3.2 blocker; active in vivo
6534 TH 5427 hydrochloride Nov 2018
Potent NUDT5 inhibitor
5991 BAY 598 Nov 2018
Potent and selective SMYD2 inhibitor
6160 VE 821 Nov 2018
High affinity and selective ATP-competitive ATR inhibitor
6363 Avagacestat Nov 2018
Highly potent γ-secretase inhibitor; orally bioavailable
5494 R 547 Nov 2018
Potent and selective cdk inhibitor; orally bioavailable
6106 T 3364366 Nov 2018
Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
6461 PARPi-FL Nov 2018
Potent fluorescent PARP inhibitor; cell permeable
6660 Crotonic Acid Nov 2018
Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length
6645 DJ-V 159 Nov 2018
GPRC6A agonist
6315 DMNB-caged-Serine Nov 2018
Caged serine; excited by visible blue light
TB1254-GMP Y-27632 dihydrochloride Nov 2018
Y-27632 synthesized to cGMP guidelines
6669 Gly MCA Nov 2018
FXR antagonist; selectively active in intestines; orally bioavailable
6658 Telaprevir Nov 2018
Hepatitis C virus (HCV) protease NS3/4A inhibitor
6675 H 151 Oct 2018
STING antagonist
6522 TH 1217 Oct 2018
Potent dCTP pyrophosphatase 1 inhibitor
6198 GSK 6853 Oct 2018
Potent and selective BRPF1 inhibitor
6700 PA Nic Oct 2018
Caged nicotine; photoactivated by one-photon and two-photon excitation
5948 DMNPE-4 AM-caged-calcium Oct 2018
Caged calcium; cell permeable
6657 PA 8 Oct 2018
PAC1 receptor antagonist
6581 PKUMDL WQ 2201 Oct 2018
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
6501 Janelia Fluor® 549, Azide Oct 2018
Cell permeable yellow fluorescent dye; supplied as an azide for 'click' chemistry
6443 IU1-47 Oct 2018
Potent USP14 inhibitor
6662 4-Octyl itaconate Oct 2018
Nrf2 activator; cell permeable
6546 Furanone C-30 Oct 2018
Quorum sensing inhibitor; antibacterial
6319 CBM 301940 Oct 2018
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
6089 Nexinhib20 Oct 2018
Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo
6444 MitoMark Green I Oct 2018
Green fluorescent mitochondrial stain; cell permeable
6445 MitoMark Red I Oct 2018
Red fluorescent mitochondrial stain; cell permeable
6353 UoS 12258 Oct 2018
Positive allosteric modulator of AMPA receptors
6256 OG 488 BAPTA-1 AM Oct 2018
Cell-permeable, fluorescent Ca2+ indicator
5550 E 2012 Oct 2018
γ-secretase modulator; Notch-sparing
6568 Dooku 1 Oct 2018
Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
6663 Silodosin Oct 2018
Selective α1A antagonist
6677 CMA Oct 2018
Murine-selective STING agonist
6594 GSHtracer Oct 2018
Radiometric glutathione (GSH) probe
6321 10-Cl-BBQ Oct 2018
Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
6364 Squarunkin A hydrochloride Oct 2018
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
6588 (+)-JQ1 carboxylic acid Oct 2018
Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs
6477 SAHM1 Oct 2018
Notch pathway inhibitor; prevents Notch complex assembly
6666 T3 Sep 2018
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
6584 L-Azidohomoalanine hydrochloride Sep 2018
Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins
6647 HADA Sep 2018
Blue fluorescent D-amino acid for labeling peptidoglycans in live bacteria
6585 L-Azidonorleucine hydrochloride Sep 2018
Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins
6615 KCC 07 Sep 2018
MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
6526 Dynarrestin Sep 2018
Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
6236 O8 OGG1 Inhibitor Sep 2018
Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
6646 CDDO-Me Sep 2018
Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
6642 QWF Sep 2018
MRGPRX2 antagonist; also NK1 receptor antagonist
6537 UNC 2881 Sep 2018
Potent Mer kinase inhibitor