Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat No | Product Name / Activity | Date Added |
|---|---|---|
| 6429 | ML 210 | Mar 2019 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | ||
| 6490 | GNE 2861 | Mar 2019 |
| Group II PAK inhibitor; potently inhibits PAK4 and PAK 6 | ||
| 6827 | Artesunate | Mar 2019 |
| Suppresses ROS-induced activation of the NLRP3 inflammasome; antimalarial | ||
| 6706 | DPNB-ABT 594 | Mar 2019 |
| Caged ABT 594; suitable for one- or two-photon photolysis | ||
| 6830 | Conivaptan hydrochloride | Mar 2019 |
| Very high affinity vasopressin V1A and V2 antagonist; orally bioavailable | ||
| 6819 | Mefloquine hydrochloride | Mar 2019 |
| Cx36 and Cx50 gap channel blocker; also antimalarial and antischistosomal | ||
| 6272 | KYP 2047 | Mar 2019 |
| High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant | ||
| 6605 | dTAG 13 | Mar 2019 |
| Degrades mutant FKBPF36V fusion proteins; useful alternative to genetic methods for target validation | ||
| 6760 | Raphin 1 | Mar 2019 |
| Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant | ||
| 6754 | LJI308 | Mar 2019 |
| Potent pan-RSK inhibitor | ||
| 6850 | Thalidomide - linker 6 | Mar 2019 |
| Thalidomide-AlkylC2-Amine | ||
| 6834 | Auxin | Mar 2019 |
| Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone | ||
| 1304 | BW-B 70C | Mar 2019 |
| 5-Lipoxygenase inhibitor | ||
| 6439 | JNJ 0966 | Mar 2019 |
| Pro-MMP9 activation inhibitor | ||
| 6812 | Afatinib dimaleate | Mar 2019 |
| Potent dual specificity EGFR/HER2 inhibitor; active in vivo | ||
| 6692 | WM 1119 | Mar 2019 |
| High affinity KAT6A (MOZ) competitive inhibitor | ||
| 6664 | Kinesore | Mar 2019 |
| Kinesin-1 modulator; cell permeable | ||
| 6851 | Pomalidomide - linker 7 | Mar 2019 |
| Pomalidomide-alkylC2-amine | ||
| 6755 | Darapladib | Mar 2019 |
| Potent lp-PLA2 inhibitor | ||
| 6518 | BI 01383298 | Feb 2019 |
| Potent and selective SLC13A5 (Na+/citrate cotransporter) inhibitor | ||
| 6724 | CBA | Feb 2019 |
| Selective TRPM4 blocker | ||
| 6802 | 6 TMR Tre | Feb 2019 |
| Fluorescent trehalose; selectively labels mycobacterial cell envelope | ||
| 6809 | L-DON | Feb 2019 |
| Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters | ||
| 6702 | Cerulenin | Feb 2019 |
| Irreversible fatty acid synthase inhibitor | ||
| 6816 | Sitagliptin phosphate | Feb 2019 |
| Potent and selective DPP IV inhibitor | ||
| 6798 | Click N-Acetylmuramic acid - alkyne | Feb 2019 |
| Bacterial peptidoglycan derivative; suitable for 'click'-conjugation to fluorescent dyes | ||
| 6266 | Taxol Janelia Fluor® 646 | Feb 2019 |
| Red fluorescent taxol derivative | ||
| 6653 | FM19G11 | Feb 2019 |
| HIF α-subunit inhibitor | ||
| 6759 | AA 147 | Feb 2019 |
| ER proteostasis regulator | ||
| 6786 | BzF | Feb 2019 |
| Photoreactive unnatural amino acid | ||
| 3719 | Talabostat mesylate | Feb 2019 |
| Potent DPP IV inhibitor; activates NLRP1b inflammasome | ||
| 6597 | SPRi 3 | Feb 2019 |
| Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells | ||
| 6793 | Dasatinib | Feb 2019 |
| Highly potent pan-Src/Bcr-Abl inhibitor | ||
| 6659 | sBADA | Feb 2019 |
| Green fluorescent D-amino acid for labeling peptidoglycans in bacteria | ||
| 6719 | YH 239-EE | Feb 2019 |
| Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity | ||
| 6470 | A 410099.1 | Feb 2019 |
| High affinity XIAP antagonist; active in vivo | ||
| 6695 | CHIR 98014 | Feb 2019 |
| Highly potent and selective GSK-3 inhibitor; improves insulin sensitivity | ||
| 6535 | NVP 2 | Feb 2019 |
| Potent and selective ATP-competitive CDK9 inhibitor | ||
| 6577 | Pyridone 6 | Feb 2019 |
| Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable | ||
| 6566 | STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable | ||
| 6567 | RI-STAD 2 | Feb 2019 |
| AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable | ||
| 6705 | Diminazene aceturate | Feb 2019 |
| ASIC blocker; antihyperalgesic | ||
| 6245 | SM 16 | Jan 2019 |
| Potent TGF-βRI inhibitor; orally bioavailable | ||
| 6715 | A 71915 | Jan 2019 |
| Highly potent and competitive NPRA antagonist | ||
| 6621 | TFAX 488, TFP | Jan 2019 |
| Green fluorescent dye; amine reactive | ||
| 6668 | ML 184 | Jan 2019 |
| Selective GPR55 agonist; also promotes NSC proliferation and differentiation | ||
| 6644 | KuWal151 | Jan 2019 |
| Potent and selective CLK inhibitor | ||
| 6553 | JF-NP-26 | Jan 2019 |
| Caged Raseglurant (Cat. No. 4416) | ||
| 6607 | dTRIM 24 | Jan 2019 |
| TRIM24 degrading PROTAC | ||
| 6726 | T-peptide | Jan 2019 |
| Cytotoxic Tau peptide; cell permeable | ||
| 6777 | TAK 375 | Jan 2019 |
| Very high affinity and selective melatonin receptor agonist | ||
| 6334 | THDOC | Jan 2019 |
| Positive modulator of GABAA receptors; endogenous neurosteroid | ||
| 5984 | LY 2955303 | Jan 2019 |
| High affinity and selective RARγ antagonist | ||
| 6698 | ELA-11 (human) | Jan 2019 |
| High affinity apelin agonist | ||
| 6709 | GSK 2018682 | Jan 2019 |
| S1P1 and S1P5 agonist | ||
| 6788 | Quizartinib | Jan 2019 |
| Highly potent FLT3 inhibitor | ||
| 6697 | ELA-21 (human) | Jan 2019 |
| High affinity apelin agonist | ||
| 6774 | 16673-34-0 NLRP3i | Jan 2019 |
| NLRP3 inflammasome inhibitor | ||
| 6243 | ML 385 | Jan 2019 |
| Nrf2 inhibitor; phenotypically lethal | ||
| 6598 | OD 36 hydrochloride | Jan 2019 |
| Potent RIP2 kinase inhibitor | ||
| 6606 | dBRD9 | Jan 2019 |
| Potent and selective BRD9 degrading PROTAC | ||
| 6369 | GNE 9278 | Jan 2019 |
| Positive allosteric modulator of NMDA receptors; acts in transmembrane domain | ||
| 6352 | (S)-ZINC 3573 | Jan 2019 |
| Negative control for (R)-ZINC 3573 | ||
| 6684 | VH 032 - linker 6 | Jan 2019 |
| VH 032-PEG2-alkyne | ||
| 6681 | Pomalidomide - linker 2 | Jan 2019 |
| Pomalidomide-PEG3-carboxylic acid | ||
| 6680 | VH 032 - linker 5 | Jan 2019 |
| VH 032-alkylC4-terminal carboxylic acid | ||
| 6699 | [D-Ala2]-GIP (human) | Jan 2019 |
| Highly potent GIP agonist | ||
| 6685 | Thalidomide, propargyl | Jan 2019 |
| Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs | ||
| 6682 | Pomalidomide - linker 3 | Jan 2019 |
| Pomalidomide-alkylC5-carboxylic acid | ||
| 6683 | VH 032, propargyl | Jan 2019 |
| Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs | ||
| 6340 | Epiblastin A | Jan 2019 |
| CK1 inhibitor; converts epiblast stem cells to ESCs and promotes ESC self-renewal | ||
| 6351 | (R)-ZINC 3573 | Jan 2019 |
| MRGPRX2 agonist | ||
| 6689 | GI 530159 | Jan 2019 |
| TREK1 and TREK2 channel activator | ||
| 6686 | Thalidomide - linker 5 | Jan 2019 |
| Thalidomide-PEG2-alkyne | ||
| 6541 | AZD 2098 | Jan 2019 |
| Potent and selective CCR4 antagonist | ||
| 6582 | D-3 | Dec 2018 |
| Selective PSC eliminating agent | ||
| 6742 | Acetazolamide | Dec 2018 |
| Carbonic anhydrase inhibitor | ||
| 6488 | 5(6)-SFX (Fluorescein), SE | Dec 2018 |
| Green fluorescent dye for the labeling of primary amines | ||
| 6712 | A 77-01 | Dec 2018 |
| Potent inhibitor of TGF-βRI | ||
| 6618 | MB 05032 | Dec 2018 |
| Potent FBPase inhibitor; promotes HSC expansion | ||
| 6590 | Janelia Fluor® 646, Maleimide | Dec 2018 |
| Red fluorescent dye, supplied with a maleimide reactive group | ||
| 6579 | BAY 826 | Dec 2018 |
| Potent Tie2 inhibitor | ||
| 6587 | TAK 242 | Dec 2018 |
| TLR4 signaling inhibitor | ||
| 6530 | R 121919 hydrochloride | Dec 2018 |
| High affinity CRF1 antagonist; orally bioavailable | ||
| 5497 | ent-LP 99 | Dec 2018 |
| Negative Control for LP 99 | ||
| 5496 | LP 99 | Dec 2018 |
| Selective BRD7 and BRD9 inhibitor | ||
| 5782 | Phalloidin-FITC | Dec 2018 |
| Green fluorescent cytoskeleton stain | ||
| 6177 | AZ 13705339 | Dec 2018 |
| Highly potent PAK1 and PAK2 inhibitor | ||
| 6625 | TFAX 594, SE | Dec 2018 |
| Red fluorescent dye; amine reactive | ||
| 6652 | NGI 1 | Dec 2018 |
| Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral | ||
| 6279 | JNJ 39758979 dihydrochloride | Dec 2018 |
| High affinity and selective histamine H4 receptor antagonist; orally bioavailable | ||
| 5783 | Phalloidin-TRITC | Dec 2018 |
| Red-orange fluorescent cytoskeleton stain | ||
| 6622 | Phalloidin-TFAX 488 | Dec 2018 |
| Green fluorescent cytoskeletal stain; binds F-actin | ||
| TB4423-GMP | CHIR 99021 | Dec 2018 |
| CHIR 99021 synthesized to cGMP guidelines | ||
| 6710 | Darunavir | Dec 2018 |
| Highly potent HIV protease inhibitor | ||
| 6676 | IC 261 | Dec 2018 |
| CK1 inhibitor; displays selectivity for CK1δ and CK1ε | ||
| 6654 | VAS 2870 | Dec 2018 |
| NADPH oxidase (Nox) inhibitor | ||
| 6624 | TFAX 568, SE | Dec 2018 |
| Orange fluorescent dye; amine reactive | ||
| 6704 | Indo 1AM | Nov 2018 |
| Fluorescent Ca2+ indicator | ||
| 6203 | GSK 9311 hydrochloride | Nov 2018 |
| Negative control for GSK 6853 | ||
| 6503 | Janelia Fluor® 549, free acid | Nov 2018 |
| Yellow fluorescent dye; supplied as a free acid | ||
| 6640 | ReZolve-ER™ | Nov 2018 |
| Fluorescent ER and plasma membrane stain | ||
| 6580 | PKUMDL WQ 2101 | Nov 2018 |
| Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH) | ||
| 6325 | TM N1324 | Nov 2018 |
| Potent and selective GPR39 agonist; orally bioavailable | ||
| 6626 | AP C5 | Nov 2018 |
| Potent and selective PKG2 inhibitor | ||
| 6651 | (2R/S)-6-PNG | Nov 2018 |
| CaV3.2 blocker; active in vivo | ||
| 6534 | TH 5427 hydrochloride | Nov 2018 |
| Potent NUDT5 inhibitor | ||
| 5991 | BAY 598 | Nov 2018 |
| Potent and selective SMYD2 inhibitor | ||
| 6160 | VE 821 | Nov 2018 |
| High affinity and selective ATP-competitive ATR inhibitor | ||
| 6363 | Avagacestat | Nov 2018 |
| Highly potent γ-secretase inhibitor; orally bioavailable | ||
| 5494 | R 547 | Nov 2018 |
| Potent and selective cdk inhibitor; orally bioavailable | ||
| 6106 | T 3364366 | Nov 2018 |
| Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable | ||
| 6461 | PARPi-FL | Nov 2018 |
| Potent fluorescent PARP inhibitor; cell permeable | ||
| 6660 | Crotonic Acid | Nov 2018 |
| Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length | ||
| 6645 | DJ-V 159 | Nov 2018 |
| GPRC6A agonist | ||
| 6315 | DMNB-caged-Serine | Nov 2018 |
| Caged serine; excited by visible blue light | ||
| TB1254-GMP | Y-27632 dihydrochloride | Nov 2018 |
| Y-27632 synthesized to cGMP guidelines | ||
| 6669 | Gly MCA | Nov 2018 |
| FXR antagonist; selectively active in intestines; orally bioavailable | ||
| 6658 | Telaprevir | Nov 2018 |
| Hepatitis C virus (HCV) protease NS3/4A inhibitor | ||
| 6675 | H 151 | Oct 2018 |
| STING antagonist | ||
| 6522 | TH 1217 | Oct 2018 |
| Potent dCTP pyrophosphatase 1 inhibitor | ||
| 6198 | GSK 6853 | Oct 2018 |
| Potent and selective BRPF1 inhibitor | ||
| 6700 | PA Nic | Oct 2018 |
| Caged nicotine; photoactivated by one-photon and two-photon excitation | ||
| 5948 | DMNPE-4 AM-caged-calcium | Oct 2018 |
| Caged calcium; cell permeable | ||
| 6657 | PA 8 | Oct 2018 |
| PAC1 receptor antagonist | ||
| 6581 | PKUMDL WQ 2201 | Oct 2018 |
| Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH) | ||
| 6501 | Janelia Fluor® 549, Azide | Oct 2018 |
| Cell permeable yellow fluorescent dye; supplied as an azide for 'click' chemistry | ||
| 6443 | IU1-47 | Oct 2018 |
| Potent USP14 inhibitor | ||
| 6662 | 4-Octyl itaconate | Oct 2018 |
| Nrf2 activator; cell permeable | ||
| 6546 | Furanone C-30 | Oct 2018 |
| Quorum sensing inhibitor; antibacterial | ||
| 6319 | CBM 301940 | Oct 2018 |
| Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable | ||
| 6089 | Nexinhib20 | Oct 2018 |
| Rab27 inhibitor; inhibits neutrophil exocytosis; active in vivo | ||
| 6444 | MitoMark Green I | Oct 2018 |
| Green fluorescent mitochondrial stain; cell permeable | ||
| 6445 | MitoMark Red I | Oct 2018 |
| Red fluorescent mitochondrial stain; cell permeable | ||
| 6353 | UoS 12258 | Oct 2018 |
| Positive allosteric modulator of AMPA receptors | ||
| 6256 | OG 488 BAPTA-1 AM | Oct 2018 |
| Cell-permeable, fluorescent Ca2+ indicator | ||
| 5550 | E 2012 | Oct 2018 |
| γ-secretase modulator; Notch-sparing | ||
| 6568 | Dooku 1 | Oct 2018 |
| Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity | ||
| 6663 | Silodosin | Oct 2018 |
| Selective α1A antagonist | ||
| 6677 | CMA | Oct 2018 |
| Murine-selective STING agonist | ||
| 6594 | GSHtracer | Oct 2018 |
| Radiometric glutathione (GSH) probe | ||
| 6321 | 10-Cl-BBQ | Oct 2018 |
| Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable | ||
| 6364 | Squarunkin A hydrochloride | Oct 2018 |
| UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation | ||
| 6588 | (+)-JQ1 carboxylic acid | Oct 2018 |
| Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs | ||
| 6477 | SAHM1 | Oct 2018 |
| Notch pathway inhibitor; prevents Notch complex assembly | ||
| 6666 | T3 | Sep 2018 |
| Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells | ||
| 6584 | L-Azidohomoalanine hydrochloride | Sep 2018 |
| Unnatural amino acid for bio-orthogonal labeling of newly synthesized proteins | ||
| 6647 | HADA | Sep 2018 |
| Blue fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6585 | L-Azidonorleucine hydrochloride | Sep 2018 |
| Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins | ||
| 6615 | KCC 07 | Sep 2018 |
| MBD2 (Methyl-CpG-binding domain protein 2) inhibitor | ||
| 6526 | Dynarrestin | Sep 2018 |
| Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein | ||
| 6236 | O8 OGG1 Inhibitor | Sep 2018 |
| Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
| 6646 | CDDO-Me | Sep 2018 |
| Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ | ||
| 6642 | QWF | Sep 2018 |
| MRGPRX2 antagonist; also NK1 receptor antagonist | ||
| 6537 | UNC 2881 | Sep 2018 |
| Potent Mer kinase inhibitor |