Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat. No. | 产品名称/活性 | Date Added |
|---|---|---|
| 7005 | 4-Thiouridine | Sep 2019 |
| Photoreactive uridine analog for RNA sequencing | ||
| 5847 | ZLD 1039 | Sep 2019 |
| Potent and selective EZH2 inhibitor; orally bioavailable | ||
| 6821 | ZAP 180013 | Sep 2019 |
| Zap70 inhibitor; inhibits interaction with ITAMs | ||
| 6950 | Thalidomide - linker 11 | Sep 2019 |
| Thalidomide-PEG3-ethylamine | ||
| 6764 | B 973B | Sep 2019 |
| Positive allosteric modulator of α7 nAChRs; analgesic | ||
| 6889 | ML 418 | Sep 2019 |
| Kir 7.1 inhibitor; also inhibits Kir 6.2 | ||
| 6972 | A 1899 | Sep 2019 |
| Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker | ||
| 6970 | aTAG 2139 | Sep 2019 |
| Degrader of MTH1 fusion proteins for use within the aTAG system | ||
| 6797 | KLD 12 | Sep 2019 |
| Self-assembling peptide; forms hydrogel to support cell growth | ||
| 6888 | ML 402 | Sep 2019 |
| Selective TREK channel activator | ||
| 6980 | BAY 87-2243 | Sep 2019 |
| Mitochondrial complex I inhibitor | ||
| 6937 | BSJ-04-132 | Sep 2019 |
| Selective Cdk4 degrader | ||
| 7020 | LDV | Sep 2019 |
| α4β1 (VLA-4) ligand | ||
| 6906 | BAY 293 Negative Control | Sep 2019 |
| Negative control for BAY 293 (Cat. No. 6857) | ||
| 6803 | MRK 740 | Sep 2019 |
| Potent PRDM9 inhibitor | ||
| 6899 | TH 257 | Sep 2019 |
| Potent and selective allosteric LIMK 1/2 inhibitor | ||
| 6857 | BAY 293 | Sep 2019 |
| Potent KRas/SOS1 interaction inhibitor | ||
| 6893 | VU 6005649 | Sep 2019 |
| Positive allosteric modulators of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant | ||
| 6765 | JTP 103237 | Aug 2019 |
| Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor | ||
| 6201 | J 2156 | Aug 2019 |
| Selective high affinity human sst4 agonist | ||
| 6938 | BSJ-03-204 | Aug 2019 |
| Selective Cdk4/6 degrader | ||
| 6927 | Glucagon (Human, Porcine) | Aug 2019 |
| Endogenous glucagon receptor agonist | ||
| 6619 | TFAX 488, SE | Aug 2019 |
| Green fluorescent dye; amine reactive | ||
| 6623 | TFAX 546, SE | Aug 2019 |
| Yellow fluorescent dye; amine reactive | ||
| 6859 | FITM | Aug 2019 |
| Potent and selective negative allosteric modulator of mGlu1 receptors | ||
| 6994 | HODHBt | Aug 2019 |
| STAT5-SUMO protein-protein interaction inhibitor | ||
| 6930 | Amphotericin B | Aug 2019 |
| Forms monovalent ion channels in lipid bilyers; antifungal | ||
| 6054 | R162 | Aug 2019 |
| Glutamate dehydrogenase (GDH1) inhibitor | ||
| 6109 | Methylnaltrexone bromide | Aug 2019 |
| μ antagonist; peripherally restricted | ||
| 6978 | AZD 5363 | Aug 2019 |
| Potent pan-AKT inhibitor | ||
| 5861 | ARN 726 | Aug 2019 |
| Potent N-acylethanolamine acid amidase (NAAA) inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 6921 | BSJ-03-123 | Aug 2019 |
| Selective Cdk6 degrader | ||
| 6922 | BSJ-Bump | Aug 2019 |
| Negative control for BSJ-03-123 | ||
| 6751 | (R)-(-)-Ketamine hydrochloride | Jul 2019 |
| NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine | ||
| 6902 | OLT 1177 | Jul 2019 |
| NLRP3 inflammasome inhibitor; disrupts inflammasome formation | ||
| 6954 | L-Buthionine sulfoximine | Jul 2019 |
| Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis | ||
| 6776 | G5 | Jul 2019 |
| Ubiquitin isopeptidase inhibitor; induces apoptosis | ||
| 6823 | CycLuc 1 | Jul 2019 |
| Synthetic luciferase substrate; brain penetrant; displays NIR emission | ||
| 6933 | CM 10 | Jul 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells | ||
| 6757 | t-TUCB | Jul 2019 |
| Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive. | ||
| 6904 | Idasanutlin | Jul 2019 |
| Potent MDM2 inhibitor; inhibits MDM2-p53 interaction | ||
| 6920 | SAH-SOS1A | Jul 2019 |
| KRas/SOS1 interaction inhibitor | ||
| 6924 | Oridonin | Jul 2019 |
| High affinity NLRP3 inflammasome inhibitor | ||
| 6701 | 1A-116 | Jul 2019 |
| Rac1 inhibitor; blocks Rac1-P-Rex1 interaction | ||
| 6986 | EG 00229 trifluoroacetate | Jul 2019 |
| Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 | ||
| 6886 | ML 67-33 | Jul 2019 |
| K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator | ||
| 6703 | BGP 15 | Jul 2019 |
| PARP inhibitor; cytoprotectant | ||
| 6909 | VH 032 phenol - linker 1 | Jul 2019 |
| VH 032 phenol-alkylC4-amine | ||
| 6969 | cis VH 032, amine dihydrochloride | Jul 2019 |
| Negative control for VH 032, amine (Cat. No. 6462) | ||
| 6910 | VH 032 phenol - linker 2 | Jul 2019 |
| VH 032 phenol-alkylC6-amine | ||
| 6228 | H10 | Jul 2019 |
| PARP14 inhibitor; cell-permeable | ||
| 6500 | Janelia Fluor® 549, Maleimide | Jul 2019 |
| Cell permeable yellow fluorescent dye; supplied with a maleimide reactive group | ||
| 6790 | GSK 126 | Jul 2019 |
| Very high affinity and selective EZH2 inhibitor | ||
| 6884 | TC SL C5 | Jul 2019 |
| Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor | ||
| 6903 | DPTIP | Jul 2019 |
| Potent and selective N-SMase2 inhibitor; brain penetrant | ||
| 6801 | Tocriscreen Epigenetics Library | Jul 2019 |
| A library of 101 epigenetic compounds (250 μL, 10 mM DMSO solutions) | ||
| 6874 | AMG 333 | Jul 2019 |
| Potent and selective TRPM8 antagonist; active in vivo | ||
| 6877 | VU 0134992 | Jul 2019 |
| Kir4.1 blocker | ||
| 6960 | ABT 199 | Jul 2019 |
| Selective, high affinity Bcl-2 inhibitor; orally bioavailable | ||
| 6908 | TR 14035 | Jul 2019 |
| Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable | ||
| 6934 | 673 A | Jun 2019 |
| ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) | ||
| 6521 | I-BET 762 | Jun 2019 |
| Potent and high affinity BRD inhibitor; anti-inflammatory; orally bioavailable. | ||
| 6957 | Reparixin L-lysine salt | Jun 2019 |
| Potent CXCR1 and CXCR2 allosteric antagonist | ||
| 6956 | Galunisertib | Jun 2019 |
| ALK4 and ALK5 (TGFβRI) inhibitor | ||
| 6966 | Thalidomide - linker 13 | Jun 2019 |
| Thalidomide-PEG1-ethylamine | ||
| 6561 | BAY 6035 | Jun 2019 |
| Potent and selective SMYD3 inhibitor | ||
| 6968 | Thalidomide - linker 15 | Jun 2019 |
| Thalidomide-alkylC6-amine | ||
| 6967 | Thalidomide - linker 14 | Jun 2019 |
| Thalidomide-PEG2-ethylamine | ||
| 6887 | ML 335 | Jun 2019 |
| Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator | ||
| 6917 | Thalidomide - linker 9 | Jun 2019 |
| Thalidomide-alkylC4-amine | ||
| 6854 | LY 3009120 | Jun 2019 |
| Potent pan-Raf kinase inhibitor | ||
| 6905 | Ceritinib | Jun 2019 |
| Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3 | ||
| 6963 | Pomalidomide - linker 8 | Jun 2019 |
| Pomalidomide-PEG4-ethylamine | ||
| 6716 | Pomalidomide - linker 4 | Jun 2019 |
| Pomalidomide-alkylC5-amine | ||
| 6713 | ZXH 3-26 | Jun 2019 |
| Potent and selective BRD4 degrader | ||
| 6489 | Ocean Blue, SE | Jun 2019 |
| Blue fluorescent dye; supplied as NHS ester | ||
| 6948 | CRBN-6-5-5-VHL | Jun 2019 |
| Potent and selective cereblon degrader; cell-permeable | ||
| 6926 | Fenoprofen calcium | May 2019 |
| Positive allosteric modulator of MC3 receptors; exhibits biased signaling | ||
| 6433 | GSK 1016790A | May 2019 |
| Potent TRPV4 agonist; active in vivo | ||
| 6495 | AM 12 | May 2019 |
| TRPC5 inhibitor | ||
| 6872 | BQCA | May 2019 |
| Positive allosteric modulator of M1 receptors | ||
| 6665 | BI 9321 | May 2019 |
| Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain | ||
| 6778 | S 38093 | May 2019 |
| Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive | ||
| 6891 | PND 1186 | May 2019 |
| Potent FAK inhibitor; orally bioavailable | ||
| 6493 | A 317491 sodium salt | May 2019 |
| Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive | ||
| 6837 | GSK 923295A | May 2019 |
| Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor | ||
| 6885 | PU 23 | May 2019 |
| Multidrug resistance protein (MRP) 4 inhibitor | ||
| 6782 | Indisulam | May 2019 |
| Molecular glue; pre-mRNA splicing modulator | ||
| 6313 | A 33 | May 2019 |
| Potent and selective PDE4B inhibitor | ||
| 6898 | Mitochondrial fusion promoter M1 | May 2019 |
| Mitochondrial fusion promoter | ||
| 6835 | ABT 737 | May 2019 |
| Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines | ||
| 6861 | Anle138b | May 2019 |
| Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation | ||
| 6817 | BAY 8002 | May 2019 |
| Potent dual MCT1/2 inhibitor; orally bioavailable | ||
| 6951 | Thalidomide - linker 12 | May 2019 |
| Thalidomide-PEG5-ethylamine | ||
| 6935 | GSK J5 HCl | May 2019 |
| Inactive isomer of GSK J4 (Cat. No. 4594); cell permeable | ||
| 6690 | Ceralifimod | May 2019 |
| Highly potent and selective S1P1 and S1P5 agonist | ||
| 6949 | Thalidomide - linker 10 | May 2019 |
| Thalidomide-alkylC2-amine | ||
| 6815 | Selumetinib | May 2019 |
| Potent and selective MEK inhibitor; orally bioavailable | ||
| 6792 | Omipalisib | May 2019 |
| Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK | ||
| 5026 | KYT 0353 | May 2019 |
| Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1); active in vivo | ||
| 6717 | FFN 270 | May 2019 |
| Fluorescent substrate for NET and VMAT2 | ||
| 6882 | DiFMUP | May 2019 |
| Fluorescent phosphatase substrate | ||
| 6881 | SB 4 | May 2019 |
| Potent BMP4 agonist | ||
| 6708 | SAH-EZH2 | May 2019 |
| EZH2/EDD interaction inhibitor; suppresses PCR2 complex function | ||
| 6362 | GSK 143 | May 2019 |
| Syk inhibitor | ||
| 6832 | Ec2la | May 2019 |
| Positive allosteric modulator of CB2 receptors; active in vivo | ||
| 6845 | RCM 1 | May 2019 |
| FOXM1 inhibitor | ||
| 6840 | AD 01 | May 2019 |
| FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic | ||
| 6771 | PHPS1 sodium salt | May 2019 |
| Shp2 (PTPN11) inhibitor | ||
| 6868 | 8-Azaadenosine | May 2019 |
| ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal | ||
| 6829 | (R)-Shikonin | May 2019 |
| PTEN inhibitor; induces necroptosis; anti-inflammatory | ||
| 6749 | TH 5487 | Apr 2019 |
| Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor | ||
| 6907 | VH 032 - linker 12 | Apr 2019 |
| VH 032-PEG2-amine | ||
| 6355 | VU 0650991 | Apr 2019 |
| Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant | ||
| 6867 | Rhein | Apr 2019 |
| FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3 | ||
| 6763 | AVE 1625 | Apr 2019 |
| Potent and selective CB1 receptor antagonist | ||
| 6378 | JMS 17-2 hydrochloride | Apr 2019 |
| CX3CR1 antagonist | ||
| 6434 | DFHO | Apr 2019 |
| Mimic of RFP fluorophore for imaging RNA in living cells | ||
| 6679 | VH 032 - linker 4 | Apr 2019 |
| VH 032-PEG3-CH2CH2COOH | ||
| 6852 | VH 032 - linker 7 | Apr 2019 |
| VH 032-alkylC2-amine | ||
| 6762 | Urolithin A | Apr 2019 |
| PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro | ||
| 6740 | Siramesine hydrochloride | Apr 2019 |
| High affinity σ agonist (σ2 > σ1) | ||
| 6634 | Surfen | Apr 2019 |
| Heparin sulfate antagonist | ||
| 6575 | StRIP16 | Apr 2019 |
| Rab8a GTPase-binding stapled peptide | ||
| 6814 | Sorafenib | Apr 2019 |
| Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT | ||
| 6510 | LNT 1 | Apr 2019 |
| Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response | ||
| 6451 | Pexacerfont | Apr 2019 |
| Potent and selective CRF1 antagonist; anxiolytic | ||
| 6864 | Ticagrelor | Apr 2019 |
| High affinity and reversible P2Y12 antagonist; displays inverse agonism in vitro; also inhibits ENT1 | ||
| 6813 | Ibrutinib | Apr 2019 |
| Potent and selective BTK inhibitor | ||
| 6745 | TL 13-112 | Apr 2019 |
| Selective ALK Degrader | ||
| 6746 | TL 13-110 | Apr 2019 |
| Negative control for TL 13-112 | ||
| 6748 | PRX 07034 | Apr 2019 |
| Potent and selective 5-HT6 antagonist | ||
| 6853 | VH 032 - linker 8 | Apr 2019 |
| VH 032-alkylC6-amine | ||
| 5862 | ARN 14686 | Apr 2019 |
| Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe | ||
| 6811 | Lapatinib | Apr 2019 |
| Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor | ||
| 6806 | AZ 3451 | Apr 2019 |
| Potent negative allosteric modulator of PAR2 receptors | ||
| 6785 | E 7820 | Apr 2019 |
| α2 integrin inhibitor; anti-angiogenic | ||
| 6747 | TL 13-22 | Apr 2019 |
| Negative control for TL 13-12 | ||
| 6744 | TL 13-12 | Apr 2019 |
| Selective ALK degrader | ||
| 6246 | BF 738735 | Apr 2019 |
| Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor | ||
| 6502 | Janelia Fluor® 549, Tetrazine | Apr 2019 |
| Cell permeable yellow fluorescent dye; supplied as a tetrazine for 'click' chemistry | ||
| 6856 | α-Mangostin | Apr 2019 |
| Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines | ||
| 6879 | VH 032 - linker 9 | Apr 2019 |
| VH 032-PEG1-amine | ||
| 6865 | uPSEM 792 hydrochloride | Apr 2019 |
| Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant | ||
| 6890 | VH 032 - linker 11 | Apr 2019 |
| VH 032-AlkylC8-Amine | ||
| 6880 | VH 032 - linker 10 | Apr 2019 |
| VH 032-alkylC10-amine | ||
| 6766 | AC 1903 | Mar 2019 |
| Selective TRPC5 blocker | ||
| 6752 | LDC 000067 | Mar 2019 |
| Potent and selective CDK9 inhibitor | ||
| 6753 | CHS 828 | Mar 2019 |
| NAMPT inhibitor; active in vivo and cytotoxic | ||
| 6787 | KI-7 | Mar 2019 |
| Positive allosteric modulator of A2B receptors | ||
| 6784 | FTBMT | Mar 2019 |
| Potent and selective GPR52 agonist; orally bioavailable and BBB permeable | ||
| 6770 | ABT 639 | Mar 2019 |
| CaV3.2 and CaV3.1 channel blocker; orally bioavailable | ||
| 6728 | RGFP 966 | Mar 2019 |
| Potent and selective HDAC3 inhibitor | ||
| 6818 | Artemether | Mar 2019 |
| Antimalarial; also inhibits neuroinflammation | ||
| 6866 | uPSEM 817 tartrate | Mar 2019 |
| Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant |