Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| Cat No | Product Name / Activity | Date Added |
|---|---|---|
| 6589 | (+)-JQ1 PA | Sep 2018 |
| 'Click' target ligand for PROTACs; functionalized BET bromodomain inhibitor | ||
| 6576 | ABT 594 hydrochloride | Sep 2018 |
| Selective α4β2 nAChR agonist | ||
| 6516 | EPZ 015666 | Sep 2018 |
| Potent and selective PRMT5 inhibitor | ||
| 6655 | Amifostine | Sep 2018 |
| Cytoprotectant | ||
| 6475 | SU 6656 | Sep 2018 |
| Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable | ||
| 6602 | 1M7 | Sep 2018 |
| Reagent for RNA SHAPE-MaP chemistry | ||
| 6531 | NLS-StAx-h | Sep 2018 |
| Wnt inhibitor | ||
| 5957 | C3 | Sep 2018 |
| Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor | ||
| 6067 | M 30 dihydrochloride | Sep 2018 |
| Potent and non-selective MAO inhibitor; also an iron chelator and antioxidant | ||
| 6126 | KRH 3955 hydrochloride | Sep 2018 |
| Highly potent CXCR4 antagonist; inhibits HIV-1 replication | ||
| 6508 | GSK 1702934A | Sep 2018 |
| Potent and selective TRPC3/6 activator | ||
| 6492 | GSK'872 | Sep 2018 |
| Potent and selective receptor activating protein kinase 3 (RIP3) inhibitor | ||
| 6257 | OG 488, SE | Sep 2018 |
| Green fluorescent dye; supplied as NHS ester | ||
| 6254 | Flutax 2 | Sep 2018 |
| Green fluorescent taxol derivative | ||
| 6255 | Fluo-4 AM | Sep 2018 |
| Cell-permeable, fluorescent Ca2+ indicator | ||
| 6648 | NADA-green | Sep 2018 |
| Fluorescent D-amino acid for labeling peptidoglycans in live bacteria | ||
| 6482 | XMU MP 1 | Sep 2018 |
| Potent and selective MST1/2 inhibitor; orally bioavailable | ||
| 6614 | Jedi2 | Sep 2018 |
| Piezo1 channel activator | ||
| 6349 | Pelitinib | Sep 2018 |
| Potent irreversible EGFR inhibitor; orally bioavailable | ||
| 4970 | BMS 688521 | Sep 2018 |
| Potent inhibitor of the LFA-1/ICAM interaction | ||
| 6557 | Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate | Aug 2018 |
| High affinity anti-human ErbB2 aptamer conjugated to Janelia Fluor® 646 | ||
| 6547 | Ambuic Acid | Aug 2018 |
| Quorum sensing inhibitor; antibacterial | ||
| 6528 | SGC AAK1 1 | Aug 2018 |
| AAK1 and BMP2K inhibitor; activates Wnt signaling | ||
| 6556 | Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate | Aug 2018 |
| High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646 | ||
| 6367 | Z 944 | Aug 2018 |
| Ca2+ channel blocker (T-type) | ||
| 6632 | ERGi-USU | Aug 2018 |
| Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein | ||
| 6532 | THAL SNS 032 | Aug 2018 |
| Potent and selective CDK9 degrading PROTAC | ||
| 6400 | Alsterpaullone | Aug 2018 |
| Potent CDK1 and 2 inhibitor; also inhibits GSK-3β and Lck | ||
| 6323 | FX 1 | Aug 2018 |
| BCL6 inhibitor; 10-fold more potent than endogenous BCL6 corepressors | ||
| 6583 | UCLA GP130 2 | Aug 2018 |
| gp130 agonist; brain penetrant and neuroprotectant | ||
| 6638 | GSK 626616 | Aug 2018 |
| Potent and selective DYRK inhibitor; orally bioavailable. | ||
| 6637 | Pomalidomide - linker 1 | Aug 2018 |
| Pomalidomide-PEG2-ethylamine | ||
| 6627 | Thalidomide - linker 4 | Aug 2018 |
| Thalidomide-alkylC6-amine | ||
| 6559 | LY 450139 | Aug 2018 |
| γ-secretase pseudo-inhibitor | ||
| 6269 | JT010 | Aug 2018 |
| Potent and selective TRPA1 channel activator | ||
| 6641 | Roflumilast | Aug 2018 |
| Potent and selective PDE4 inhibitor | ||
| 6229 | LP 922761 | Aug 2018 |
| Potent AAK1 inhibitor; peripherally restricted | ||
| 4690 | Fmk | Aug 2018 |
| Irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor | ||
| 6539 | Obatoclax mesylate | Jul 2018 |
| Inhibitor of Bcl-2 family members; antiapoptotic | ||
| 6454 | LY 2603618 | Jul 2018 |
| Potent and selective Chk1 inhibitor | ||
| 6426 | PSEM 89S | Jul 2018 |
| PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | ||
| 6555 | TokeOni | Jul 2018 |
| NIR-emission luciferin analog; orally bioavailable and brain penetrant | ||
| 6524 | TL 12-186 | Jul 2018 |
| Multikinase degrading PROTAC | ||
| 6425 | PSEM 308 hydrochloride | Jul 2018 |
| PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | ||
| 6428 | Carboprost tromethamine | Jul 2018 |
| Synthetic Prostaglandin F2α (Cat. No. 4214) analog | ||
| 6422 | DREADD agonist 21 dihydrochloride | Jul 2018 |
| Potent muscarinic DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548) | ||
| 6628 | TC E3 5032 | Jul 2018 |
| Precursor to Pomalidomide-based PROTACs | ||
| 6525 | TL 13-27 | Jul 2018 |
| Negative control for TL 12-186 | ||
| 6330 | AZ 5704 | Jul 2018 |
| Potent and selective ATM kinase inhibitor; orally bioavailable | ||
| TB2634-GMP | DAPT | Jul 2018 |
| DAPT synthesized to cGMP guidelines | ||
| TB1614-GMP | SB 431542 | Jul 2018 |
| SB 431542 synthesized to cGMP guidelines | ||
| 6545 | OB-1 | Jul 2018 |
| Stomatin-like protein-3 (STOML3) oligomerization inhibitor | ||
| 6483 | Isoginkgetin | Jul 2018 |
| Pre-mRNA splicing inhibitor; cell permeable | ||
| 5910 | TL4-12 | Jul 2018 |
| Potent MAP4K2 (GCK) inhibitor | ||
| 6153 | JQEZ5 | Jul 2018 |
| Potent and selective SAM-competitive EZH2 inhibitor | ||
| 4007 | Laulimalide | Jul 2018 |
| Microtubule stabilzing agent | ||
| 6520 | Abiraterone acetate | Jul 2018 |
| Potent CYP17A1 inhibitor | ||
| 6491 | YM 155 | Jul 2018 |
| Survivin suppressor | ||
| 6486 | Aprepitant | Jul 2018 |
| Potent long-acting hNK-1 antagonist | ||
| 6479 | CU CPT 9a | Jul 2018 |
| Potent TLR8 inhibitor | ||
| 6542 | Ivabradine hydrochloride | Jul 2018 |
| HCN channel blocker; inhibits If pacemaker current | ||
| 6517 | Liraglutide | Jul 2018 |
| Highly potent, long-acting GLP-1 receptor agonist | ||
| 6476 | Compound E | Jul 2018 |
| γ-secretase inhibitor; induces neuronal differentiation | ||
| 6199 | BAY 876 | Jul 2018 |
| Potent and selective GLUT1 inhibitor | ||
| 6538 | PF 04449913 maleate | Jul 2018 |
| Potent Smo antagonist | ||
| 6506 | PF 06551600 malonate | Jul 2018 |
| Potent and selective JAK3 inhibitor | ||
| 6480 | GSK 583 | Jul 2018 |
| Potent RIP2 kinase inhibitor; orally bioavailable and cell permeable | ||
| 6436 | CY 09 | Jul 2018 |
| NLRP3 inhibitor; active in vivo | ||
| 6578 | GT 949 | Jul 2018 |
| Potent and selective positive allosteric modulator of EAAT2 | ||
| 6544 | CID 1375606 | Jul 2018 |
| GPR27 agonist | ||
| 6324 | Autophinib | Jul 2018 |
| Potent VPS34 inhibitor | ||
| 6281 | SLM 6031434 hydrochloride | Jul 2018 |
| Selective sphingosine kinase 2 (Sphk2) inhibitor | ||
| 6273 | CRT 0105950 | Jul 2018 |
| Potent LIMK1/2 inhibitor | ||
| 5767 | SR 3029 | Jul 2018 |
| Potent and selective CK1δ and CK1ε inhibitor | ||
| 6564 | SGC GAK 1 | Jul 2018 |
| High affinity cyclin G associated kinase (GAK) inhibitor | ||
| 6558 | CP 43 | Jul 2018 |
| Potent TAOK inhibitor | ||
| 6320 | ESI 05 | Jul 2018 |
| EPAC2 inhibitor | ||
| 6040 | BRD 9757 | Jul 2018 |
| Potent and selective HDAC6 inhibitor | ||
| 6179 | UK 59811 hydrochloride | Jul 2018 |
| CaVAb blocker | ||
| 6239 | SAK 3 | Jul 2018 |
| Potent CaV3.1/3.3 activator; orally bioavailable | ||
| 6554 | (+)-Abscisic Acid | Jun 2018 |
| Endogenous LANCL2 agonist | ||
| 6505 | Avasimibe | Jun 2018 |
| ACAT inhibitor | ||
| 6448 | ML 351 | Jun 2018 |
| Selective 12/15 LOX inhibitor; active in vivo | ||
| 6144 | CX08005 | Jun 2018 |
| Competitive PTP1B inhibitor | ||
| 5828 | Ambrisentan | Jun 2018 |
| Selective ETA antagonist | ||
| 6079 | TC KHNS 11 | Jun 2018 |
| Potent and selective PI 3-kinase δ inhibitor; orally bioavailable | ||
| 6037 | LM22B 10 | Jun 2018 |
| TrkB and TrkC agonist; brain penetrant | ||
| 6406 | Hydroxystilbamidine bis(methanesulfonate) | Jun 2018 |
| Fluorescent cationic dye; neuronal tracer | ||
| 6549 | cAC 253 | Jun 2018 |
| Amylin (AMY3) receptor antagonist; brain penetrant | ||
| 6296 | Janelia Fluor® 525, SE | Jun 2018 |
| Cell permeable yellow fluorescent dye; supplied as NHS ester | ||
| 6572 | Biotin-LC-NAD+ | Jun 2018 |
| Biotinylated analog of β-NAD+. Commonly used reagent in LSD1 and PARP1 assays | ||
| 6571 | Biotin-11-dUTP | Jun 2018 |
| Biotin-labeled dUTP | ||
| 6551 | PAMP-12 (human, porcine) | Jun 2018 |
| Potent MRGPRX2 agonist | ||
| 6113 | Liproxstatin-1 hydrochloride | Jun 2018 |
| Potent ferroptosis inhibitor | ||
| 6552 | PAMP-20 (human) | Jun 2018 |
| MRGPRX2 agonist | ||
| 6550 | AC 253 | May 2018 |
| Amylin (AMY3) receptor antagonist | ||
| 6244 | OG-L002 | May 2018 |
| Potent LSD1 inhibitor | ||
| 6017 | THPN | May 2018 |
| Nur77 agonist; induces autophagy in melanoma cell lines | ||
| 6548 | N-(3-Oxododecanoyl)-L-homoserine lactone | May 2018 |
| Bacterial quorum sensing autoinducer; immunomodulator | ||
| 6484 | Terbinafine hydrochloride | May 2018 |
| Selective TASK3 activator; also inhibits fungal squalene epoxidase | ||
| 6507 | Saxagliptin hydrochloride | May 2018 |
| High affinity DPP-IV inhibitor; active in vivo | ||
| 6383 | SR 16832 | May 2018 |
| Dual site PPARγ inhibitor | ||
| 3036 | Loxiglumide | May 2018 |
| CCK1 antagonist; active in vivo | ||
| 6223 | XY 018 | May 2018 |
| RORγ antagonist; inhibits AR expression | ||
| 6387 | A 485 | May 2018 |
| Potent and selective p300/CBP inhibitor; orally bioavailable | ||
| 6440 | PIK 93 | May 2018 |
| Potent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor | ||
| 6166 | AMG 18 hydrochloride | May 2018 |
| Potent and selective IRE1α inhibitor | ||
| 6139 | NS 6740 | May 2018 |
| High affinity α7 nAChR partial agonist; anti-inflammatory | ||
| 6469 | Thalidomide - linker 3 | Apr 2018 |
| Thalidomide-alkylC4-amine | ||
| 6463 | VH 032 - linker 1 | Apr 2018 |
| VH 032-PEG3-amine | ||
| 6468 | Thalidomide - linker 2 | Apr 2018 |
| Thalidomide-PEG4-ethylamine | ||
| 6465 | VH 032 - linker 3 | Apr 2018 |
| VH 032-alkylC4-amine | ||
| 6455 | Tocriscreen Plus Micro | Apr 2018 |
| A library of 1280 biologically active compounds (15 μL 10 mM DMSO solutions) | ||
| 6438 | BRD 6989 | Apr 2018 |
| Cdk8 inhibitor; enhances IL-10 production | ||
| 6467 | Thalidomide - linker 1 | Apr 2018 |
| Thalidomide-PEG3-ethylamine | ||
| 6464 | VH 032 - linker 2 | Apr 2018 |
| VH 032-PEG4-amine | ||
| 6494 | Galangin | Apr 2018 |
| TRPC5 inhibitor; also induces autophagy | ||
| 6417 | CMP 98 | Apr 2018 |
| Negative Control for CM 11 | ||
| 6416 | CM 11 | Apr 2018 |
| Homo-PROTAC for self-degradation of pVHL30 | ||
| 6515 | (D)-PPA 1 | Apr 2018 |
| PD-1/PD-L1 interaction inhibitor | ||
| 6409 | A 1210477 | Apr 2018 |
| Selective, high affinity Mcl-1 inhibitor; proapoptotic | ||
| 4647 | GR 203040 | Apr 2018 |
| Potent and selective NK1 antagonist | ||
| 3649 | CP 122721 hydrochloride | Apr 2018 |
| High affinity NK1 antagonist | ||
| 6392 | B02 | Apr 2018 |
| RAD51 recombinase inhibitor | ||
| 6435 | ML 323 | Apr 2018 |
| Potent and selective USP1-UAF1 allosteric inhibitor | ||
| 5730 | A 127722 | Mar 2018 |
| Highly potent, selective ETA antagonist; orally bioavailable |