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Submit ReviewTricyclic cytosine tC
Description: Fluorescent tricyclic cytosine analog for RNA imaging
Chemical Name: 3-β-D-Ribofuranosyl-1H-pyrimido[5,4-b][1,4]benzothiazin-2(3H)-one
Purity: ≥95% (HPLC)
Biological Activity for Tricyclic cytosine tC
Tricyclic cytosine tC is a fluorescent cytosine analog for imaging RNA in living cells. Enables the investigation of RNA synthesis, degradation, and trafficking at single-cell resolution when combined with confocal imaging. Excitation/emission maxima (λ) = 375/505 nm; extinction coefficient = 4000 M-1 cm-1; quantum yield = 0.2.
Optical Data for Tricyclic cytosine tC
| λabs | 375 nm |
|---|---|
| λem | 505 nm |
| Extinction Coefficient (ε) | 4000 M-1cm-1 |
| Quantum Yield (φ) | 0.2 |
| Application | Confocal Imaging |
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Technical Data for Tricyclic cytosine tC
| M. Wt | 349.36 |
| Formula | C15H15N3O5S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1174063-74-1 |
| InChI Key | SRXXFIYNNTZZBB-LHNIVKCTSA-N |
| Smiles | O[C@H]1[C@H](N2C(N=C3C(SC4=CC=CC=C4N3)=C2)=O)O[C@@H]([C@H]1O)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Tricyclic cytosine tC
References for Tricyclic cytosine tC
References are publications that support the biological activity of the product.
Wang et al (2022) Live-cell RNA imaging with metabolically incorporated fluorescent nucleosides. J.Am.Chem.Soc. 144 14647 PMID: 35930766
Stengel et al (2010) Incorporation of the fluorescent ribonucleotide analogue tCTP by T7 RNA polymerase. Anal.Chem. 82 1082 PMID: 20067253
Sandin et al (2005) Fluorescent properties of DNA base analogue tC upon incorporation into DNA--negligible influence of neighbouring bases on fluorescence quantum yield. Nucleic Acids Res. 33 5019 PMID: 16147985
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Fluorescent Dyes and Probes Research Product GuideNew
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
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