Scientific Meeting Posters

A range of scientific meeting posters authored by in-house experts

Written by our in-house experts and external collaborators, the following range of posters have been presented at scientific meetings, and provide an informative summary of key areas of research. We invite you to request your copy today.

Developing Degraders Scientific Posters

Developing Degraders

Principles and Perspectives on Design and Chemical Space

Maple, H et al.

This poster describes the generation of a database of Degraders (PROTACs®) from the literature. The Degraders were profiled according to the constituent ligands, linker type, linker length and physicochemical properties and this information was used to establish a set of guidelines for the design and synthesis of cell-permeable Degrader molecules. Presented at the 20th SCI/RSC Medicinal Chemistry Symposium 2019, Cambridge, UK.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Enabling Research By Provision of Chemical Tools Scientific Posters

Enabling Research By Provision of Chemical Tools

Developing New Chemical Tools for Biological Research

Maple, H et al.

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.
Targeted Protein Degradation Scientific Poster

Targeted Protein Degradation

Generating a Chemical Toolbox to Support PROTAC R&D

Maple, H et al.

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia