The synthetic capability of our chemistry team is vast
We synthesise the majority of the 4000 item catalog range in-house and as a result our chemists are highly experienced in preparing biologically active molecules that are both structurally and synthetically diverse.
Examples from our catalogue to illustrate the diversity of our work
Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors.
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumour effects in vivo; antitumour agent.
Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
High affinity 5-HT2A receptor agonist. Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors.
Highly selective group II mGlu receptor agonist that displays > 80-fold selectivity over group I and group III receptors.
Antitumour agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription.