D609

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Cat.No. 1437 - D609 | C11H15OS2K | CAS No. 83373-60-8
Description: Selective PC-PLC inhibitor
Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Technical Data

M. Wt 266.46
Formula C11H15OS2K
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 83373-60-8
PubChem ID 4234241
InChI Key IGULCCCBGBDZKQ-UHFFFAOYSA-M
Smiles S=C(S[K])OC1CC2C3CCCC3C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 266.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.53 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287 PMID: 9034754

Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664 PMID: 7532078

Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103 PMID: 11408530

Adibhatla et al (2012) Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem.Res. 37 671 PMID: 22101393


If you know of a relevant reference for D609, please let us know.

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: D609, D609 supplier, Selective, PC-PLC, inhibitors, inhibits, Phospholipases, C, Esterases, Phospholipase, Antivirals, Other, Synthases/Synthetases, 1437, Tocris Bioscience

4 Citations for D609

Citations are publications that use Tocris products. Selected citations for D609 include:

Navratil et al (2014) Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases. Infect Immun 82 3299 PMID: 24866789

Sovadinova et al (2015) Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. J Pharmacol Exp Ther 10 e0124454 PMID: 26023933

Pastor et al (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res 55 966 PMID: 24610889

Upham et al (2009) Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems. Environ Health Perspect 117 545 PMID: 19440492


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Reviews for D609

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Literature in this Area

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