D609

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Cat.No. 1437 - D609 | C11H15OS2K | CAS No. 83373-60-8
Description: Selective PC-PLC inhibitor
Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Technical Data

M. Wt 266.46
Formula C11H15OS2K
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 83373-60-8
PubChem ID 4234241
InChI Key IGULCCCBGBDZKQ-UHFFFAOYSA-M
Smiles S=C(S[K])OC1CC2C3CCCC3C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 26.65 100
water 26.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 266.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.53 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Amtmann (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 22 287 PMID: 9034754

Li et al (1998) Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. Proc.Natl.Acad.Sci.U.S.A. 95 7748 PMID: 9636222

Tschiakowsky et al (1994) Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 113 664 PMID: 7532078

Zhou et al (2001) D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 298 103 PMID: 11408530


If you know of a relevant reference for D609, please let us know.

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: Selective PC-PLC inhibitors inhibits Phospholipases C Esterases Phospholipases

2 Citations for D609

Citations are publications that use Tocris products. Selected citations for D609 include:

Sovadinova et al (2015) Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. J Pharmacol Exp Ther 10 e0124454 PMID: 26023933

Navratil et al (2014) Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases. Infect Immun 82 3299 PMID: 24866789


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